Datatransfer complewww.cc.ukans.edu default index (1/16/94) (p1
of 2)WELCOME TO THE UNIVERSITY OF KANSAS

   You are using a World-Wide Web client called Lynx on a server
operated
   by Academic Computing Services at the University of Kansas,
which is
   the home of* KUfacts, the KU campus wide information system,
and

     * the Lynx and DosLynx World-Wide Web (WWW) browsers.

   The current version of Lynx is 2.3.7. If you are running an
earlier
   version PLEASE UPGRADE!

   The Lynx 2-3-7 source code is now available for BETA testing.

  INFORMATION SOURCES ABOUT AND FOR THE WWW
     * For a description of the WWW choose Web Overview
     * About the WWW Information Sharing project
     * WWW Information By Subject

  Arrow keys: Up and Down to move. Right to follow a link; Left
to go back.
 H)elp O)ptions P)rint G)o M)ain screen Q)uit /=search
[delete]=history list 
-- press pace for next page --Ente a searhstig: g  
open: http://www.cdc.gov
Getting http://www.cdc.gov/
Lookup www.cdcgov
Making HTTP connetin to www.cdc.gov.
Sending HTP request.
HTTP requestsnt; waiting for response.
Read256 bye of data.of 1692 bytes of data.
1024 of 1692 bytes of data.
Datatransfer comple                   CDC & ATSDR Home
Page3Welcome to the Centers for Disease Control and Prevention
and the
   Agency for Toxic Substances and Disease Registry.
   
   
    
_________________________________________________________________

    Healthy People in a Healthy World - - through Prevention

     
    
_________________________________________________________________
   
   o About CDC & ATSDR

   o Centers for Disease Control and Prevention (CDC)
          o Agency for Toxic Substances and Disease Registry
(ATSDR)
     
     
     
-- press pace for next page --



Getting http://www.cdc.gov/aboutcdc.htm
Lookup www.cdcgov
Making HTTP connetin to www.cdc.gov.
Sending HTP request.
HTTP requestsnt; waiting for response.
Read256 bye of data.of 2301 bytes of data.
Datatransfer comple            About CDC4   The Centers for
Disease Control and Prevention (CDC), located in Atlanta,  
Georgia, USA, is an agency of the Public Health Service, in
theDepartment of Health and Human Services.
    
_________________________________________________________________
    
      CDC Mission:
      To promote health and quality of life by preventing and
controlling
      disease, injury, and disability

   
    
_________________________________________________________________
The CDC includes 11 Centers, Institutes and Offices:  




-- press pace for next page -- Getting
http://www.cdc.gov/cdcmiss.htm
Lookup www.cdcgov
Making HTTP connetin to www.cdc.gov.
Sending HTP request.
HTTP requestsnt; waiting for response.
Read256 bye of data.of 663 bytes of data.
512
89
Datatranser complteCDC Mission2CDC Mission
    
_________________________________________________________________

   As the Nation's prevention agency, we accomplish our mission
by
   working with partners throughout the nation and the world to:
      
     * monitor health
     * detect and investigate health problems
     * conduct research to enhance prevention
     * develop and advocate sound public health policies
     * implement prevention strategies
     * promote healthy behaviors
     * foster safe and healthful environments 
     * provide leadership and
training_________________________________________________________
________

-- press pace for next page --2<== Return to CDC & ATSDR Home
Page
    

Command: Use arrow keys to move, '?' for help, 'q' to quit, '<-'
to go back Gettig http://www.cdc.gov/cdc.htm
Lookup www.cdcgov
Making HTTP connetin to www.cdc.gov.
Sending HTP request.
HTTP requestsnt; waiting for response.
Read256 bye of data.of 1692 bytes of data.
Datatransfer compleCDC & ATSDR Home Page (p1 of 3Welcome to the
Centers for Disease Control and Prevention and the
   Agency for Toxic Substances and Disease
Registry.________________________________________________________
_________

    Healthy People in a Healthy World - - through
Prevention_______________________________________________________
__________

   o About CDC & ATSDRo Centers for Disease Control and
Prevention (CDC)o Agency for Toxic Substances and Disease
Registry (ATSDR)




-- press pace for next page --2o Publications and Scientific Data
   
   o Other Related Information Resources

   Search Not Yet Implemented
     
   Search ________________________________________
   
    
_________________________________________________________________

   In general all information presented in these pages and all
items
   available for download are for public use. However, you may
encounter
   some pages that require a login password and id. If this is
the case
   you may assume that information presented and items available
for
   download therein are for your authorized access only and not
for
(NORMAL LINK)  Use right-arrow or <return> to activate1
   Welcome to the Centers for Disease Control and Prevention and
the
   Agency for Toxic Substances and Disease Registry.Healthy
People in a Healthy World - - through Prevention

   
    
_________________________________________________________________
   
   o About CDC & ATSDR
     

          o Centers for Disease Control and Prevention (CDC)
          o Agency for Toxic Substances and Disease Registry
(ATSDR)
   
   
   

-- press spacefor next page --




Getting http://www.cdc.gov/aboutcdc.htm            About CDC4  
The Centers for Disease Control and Prevention (CDC), located in
Atlanta,   Georgia, USA, is an agency of the Public Health
Service, in theDepartment of Health and Human Services.
    
_________________________________________________________________
    
      CDC Mission:
      To promote health and quality of life by preventing and
controlling
      disease, injury, and disability

   
    
_________________________________________________________________
The CDC includes 11 Centers, Institutes and Offices:  




-- press space for next page -- 2National Center for Chronic
Disease Prevention and Health    Promotion    National Center for
Environmental Health    National Center for Health
StatisticsNational Center for Infectious DiseasesNational Center
for Injury Prevention and Control
          National Center for Prevention ServicesNational
Institute for Occupational Safety and Health
          Epidemiology Program Office
          International Health Program Office
          Public Health Practice Program OfficeNational
Immunization Program

     
    
_________________________________________________________________
      
      CDC Employees and Locations:

     * Approximately 7,000 employees in 170 occupations
     * Locations:
 Getting http://www.cdc.gov/dcpa.htm
Lookup www.cdcgov
Making HTTP connetin to www.cdc.gov.
Sending HTP request.
HTTP requestsnt; waiting for response.
Read256 bye of data.of 5509 bytes of data.
Datatransfer comple  National Center for Chronic Disease
Prevention and Health Promotion (p1 of 8
    National Center for Chronic Disease Prevetion and Health
Promotion
    
_________________________________________________________________
Mission:To prevent premature death and disability from chronic
diseases and to
      promote healthy personal behaviors.
    
_________________________________________________________________
Major NCCDPHP Activities, FY 1994
     
     *
      
      State-based surveillance systems
     
       Behavioral risk factor surveillance and chronic disease
morbidity

-- press pace for next page --2surveillance using state-level
hospital discharge, morbidity, and
       cancer registry data; development of state-level
healthinformation retrieval systems*Prevention of tobacco use
       Surveillance of tobacco use and analysis of policy
andprogrammatic interventions; building tobacco control capacity
ofstate health departments through financial and programmatic
       assistance; public education programs targeting
high-riskpopulations, including young people, minorities, and the
elderly;
       coordination of federal and non-federal partnersPrevention
of nutrition-related health problemsPediatric and pregnancy
surveillance; dietary surveillance; iron 
3deficiency anemia prevention and control; promoting diets low in
fat and high in fruits and vegetables; school nutrition
education;weight manage-ment studies; food industry
partnership;participation in the Program Against Multiple
Micronutrient
       Malnutrition*Maternal and infant healthPrenatal Smoking
cessation Program, Pregnancy Risk AssessmentMonitoring System,
Maternal and Child Health Epidemiology Program,contraceptive
safety and efficacy studies, teen pregnancy surveil-lance, family
planning/maternal and child health surveys, study ofHlV in women
and infants; maternal and infant morbidity and
       mortality studies of low birthweight and pre-term delivery

     *Women's health 
4Analysis and dissemination of information regarding the
long-term health effects of tubal sterilization; Data
Coordinating Centerfor study of the relationship between oral
contraceptives use andrisk of breast cancer, funded by the
National Institute of ChildHealth and Human Development; analysis
of common gynecologic
       (non-pregnancy) conditions listed as discharge diagnoses
in theNational Hospital Discharge Survey
      
     *
      Women's health and HlV infection Study of family planning
clinics providing HlV prevention servicesfor women; development
and evaluation of clinic-levelinterventions for the prevention of
HlV infection in women andinfants; evaluation of percep- tions of
the male role in
       contraception decision-making and condom use for
diseaseprevention; defining the role of contraceptives and other
factors
       associated with heterosexual transmission of HlV infection
from
5infected males to their female partners; analysis of
naturalhistory data; analysis of etiology and clinical course of
pelvic inflammatory disease in women with and without HlV
infection   
     * Diabetes control and preventionAnalysis and publication of
national diabetes surveillance data
       and support of state-based surveillance efforts;
demonstration ofcommunity-based interventions; training at-risk
communities to
       assess and impact their own specific burdens; state-based
diabetescontrol programs to lead both health systems and
communitiestoward improved diabetes prevention and control in a
evolvinghealth system; coordina- tion of all public health
efforts totranslate the best results of diabetes research into
widespreadpractice 
     * 
6Breast and cervical cancer controlState-based comprehensive
breast and cervical cancer controlprograms; surveillance and
epidemiology; national education
       efforts for health care providers and the public;
qualityassurance of mammography and Pap smear screening
     *
      National Program of Cancer RegistriesFunding for nationwide
population-based cancer registries tomonitor local trends in
disease burden and provide vitalinformation for interventions and
health care resource allocations
     * 
      Comprehensive school health program
     Building infrastructure for comprefiensive school health
programs;
7 strengthening comprehensive school health education to
preventimportant health problems; youth risk behavior
surveillancesystem; guide- lines for tobacco use prevention,
nutrition  education, physical activity, and comprehensive school
healthducation
     *
     
      Assistance in community chronic disease interventions
      Planned Approach To Community Health; worksite lifestyle
programs;community cardiovascular disease risk reduction programs
centeredon nutrition, smoking, hypertension, and physical
activity; healthpromo- older adultsPreventive health and health
services block grants and prevention
      research centers
8Intervention programs to reduce incidence of chronic
diseases;detection of hypertension and elevated cholesterol;
education andrisk reduction targeting smoking, exercise, and
diet;university-based centers for prevention research and
demonstrationprojects
_____________________________________________________________
      <== Return to CDC & ATSDR Home Page

     
      

Command: Use arrow keys to move, '?' for help, 'q' to quit, '<-'
to go back Gettig http://www.cdc.gov/cdc.htm                      
                         CDC & ATSDR Home Page (p1 of 3
   Welcome to the Centers for Disease Control and Prevention and
the 
   Agency for Toxic Substances and Disease Registry.
    
_________________________________________________________________

    Healthy People in a Healthy World - - through Prevention
    
_________________________________________________________________

   o About CDC & ATSDRo Centers for Disease Control and
Prevention (CDC)o Agency for Toxic Substances and Disease
Registry (ATSDR)




-- press space for next page --   



Getting http://158.111.33.2:8080/atsdrhome.html
Lookup 158.1133.2:8080.
Making HTTP connection to 158.111.33.2:8080.
Sending HTP request.
HTTP requestsnt; waiting for response.
Read256 bye of data.of 9953 bytes of data.
Datatransfer comple   ATSDR - Home Page (p1 of 12[IMAGE] 
   
Agency for Toxic Substances and Disease Registry
    
_________________________________________________________________
    
Contents

     * ATSDR Announcements
     * ATSDR Summary
          + Background and Congressional Mandates+ Organizational
Structure+ Goals+ Stament of Values
     * ATSDR Locations(addresse d phoes)
     * ATSDR Datasets/Resources+ The HazDat Databaseo Query and
Search (thru HTML forms)

-- press pace for next page --2o Contacts and References
          + Toxicologyo ToxFAQs (tm)
               o Public Health Statements (Text Search)+ Health
Education and Communication+ Reports and Congressional Testimony
               o Biennial Report to Congress: 1991-1992
(ExecutiveStatement)
               o Congressional Testimony
     * Related Organizations and Internet Resources
          + Ceters for Disease Control and Prevention (CDC)
          + U.S. Environmental Protection Agency (EPA)Ntional
Institute of Environmetl Health Sciences (NIEHS)
     * ATSDR Contacts
     * ATSDR WWW Server Usage Statistics
     
     
    
_________________________________________________________________
Getting http://www.iehs.nih.gov/
Lookup www.niehs.nihgov
Making HTTP conectio to www.niehs.nih.gov.
Sending HTP request.
HTTP requestsnt; waiting for response.
Read209 bye of data.
56 of 3184 bytes of data.
Data transfer compleThe National Institute of Environmental
Health Sciences (p1 of 3
The National Institute of Environmental Health Sciences
[IMAGE]
   Welcome to the NIEHS WWW server!
   If you'd like to find someone here at the NIEHS, look them up
in this
   up-to-date Phone Book. From this Home Page, you can access the
NIEHS
   Gopher Server and the Home Pages of several organizations
within the
   National Institute of Evironmeal Health Scinces.
   [IMAGE] The NIEHS' parent organization is the National
Institutes of
   Health.The Molecular Biophysics Laboratory Home Page provides
access to
       various biophysics-related databases with sophisticated
searchengines and detailed reporting.
     * Take a trip to the NIEHS Molecular Biology Home Page
onboard theEnterprise.
     * The NIEHS Library supports the research of the Institute
by
       keeping up-to-date databases of Medical and Environmental

-- press pace for next page --2research.
     * The National Toxicology Program Home Page is also
available here.
     * Mathematical, statistical and computational modeling are
done bythe Laboratory of Quantitative and Computational Biology.
       Databases, computer code and descriptions of current
researchprojects are available at this web site.
     * The NIEHS Scientific Database Server (currently under
development)
       allows access to several databases currently maintained at
NIEHS.
       The Web interface to these databases allows Web users to
do
       searches on the data contained in the database and return
theresults in HTTP format.
     * NIEHS Connections News Letter
   
   This WWW server is provided as a service of the Office of
Computer  
   Technology and Services.
   Also take a look a some of the Technical Staff and find out
about
   NIEHS Training Opportunities.
     
    
_________________________________________________________________
3
   Surf the Net:North Carolina Servers.
     * Federl Govenment Servers.
     * All the Servers in the World.
     * Triangle Area Entertainment/Information South ast Weather
Map
    
_________________________________________________________________
   [IMAGE] Problems/Questions? Send mail to www@niehs.nih.gov

   
   
   
   

Command: Use arrow keys to move, '?' for help, 'q' to quit, '<-'
to go backGettig http://158.111.33.2:8080/atsdrhme.html           
                         ATSDR - Home Page (p2 of 12o Contacts
and References
          + Toxicology
               o ToxFAQs (tm) 
               o Public Health Statements (Text Search)
          + Health Education and Communication
          + Reports and Congressional Testimony
               o BinnialReort to Congress: 1991-1992
(ExecutiveStatement)o Congressional Testimony
     * Related Organizations and Internet Resources+ Centers for
Disease Control and Prevention (CDC)
          + U.S. Environmental Protection Agency (EPA)+ National
Institute of Environmental Health Sciences (NIEHS)
     * ATSDR Contacts
     * ATSDR WWW Server Usage
Statistics_______________________________________________________
__________

-- press space for next page --Getting
http://158.111.33.2:8080/toxfaq.html
Lookup 158.1133.2:8080.
Making HTTP connection to 158.111.33.2:8080.
Sending HTP request.
HTTP requestsnt; waiting for response.
Read256 bye of data.of 3106 bytes of data.
Datatransfer compleATSDR - ToxFAQs (tm) (p1 of 4                  
[IMAGE] TOXFAQS (TM)
    
_________________________________________________________________
   ToxFAQs (tm) is a series of summaries about hazardous
substances being
   developed by the ATSDR Division of Toxicology. Information for
this
   series is excerpted from the ATSDR Toxicology Profiles and
Public
   Health Statements.
   Each fact sheet serves as a quick and easy to understand
guide.
   Answers are provided to the most frequently asked questions
about
   exposure to hazardous substances found around hazardous waste
sites
   and human health effects.

   This is a new service. More information will be available in
future
   updates.

-- press pace for next page --2NOTE: If you do not find
information here on a specific chemical, try
   searching the ATSDR/EPA Top 20 Hazardous Substances or the
ATSDR
   Public Health Statement Text Search.
    
_________________________________________________________________ 
                     ATSDR TOXFAQS MENU

   
   
   1 Aldrin/Dieldrin
   
   2 Arsenic
   
   3 Benzene
   
   4 Beryllium

   5 Cadmium 
   
36 Chloroform
   
   7 Chromium
   
   8 Cyanide

   9 DEHP, Di(2-ethylhexyl)phthalate

   10 1,4-Dichlorobenzene

   11 Fluorides, Hydrogen Fluoride, and Fluorine

   12 Heptahlor and Heptachlor Epoxide

   13 Lead  

   14 Methylene Chloride

   15 Nickel

416 N-Nitrsodiphenylamine

   17 Polychlorinated Biphenyls (PCBs)

   18 Tetrachloroethylene

   19 Trichloroethylen (TCE)

   20 Vinyl Cid

   
    
_________________________________________________________________
   
   Link to ATSDR Science Corner
    
_________________________________________________________________

   [IMAGE] ATSDR Home Page
    
_________________________________________________________________
   
    Charlie Xintaras / chx1@atsoaa1.em.cdc.gov

Command: Use arrow keys to move, '?' for help, 'q' to quit, '<-'
to go back36 Chlorofrm

   7 Chromium

   8 Cyanide

   9 DEHP, Di(2-ethylhxyl)phthalate

   10 1,4-Dicobnzene

   11 Fluorides, Hydrogen Fluoride, and Fluorine
     
   12 Heptachlor and Heptachlor Epoxide
   
   13 Lead

   14 Methylene Chloride  
     
   15 Nickel
    

-- pres space for next page --



Getting http://atsdr1.atsdr.cdc.gov:8080/tfacts13.html
Lookup atsdr1.atsdr.ccgov:8080.
Making HTTP connection to atsdr1.atsdr.cdc.gov:8080.
Sending HTP request.
HTTP requestsnt; waiting for response.
Read256 bye of data.of 8034 bytes of data.
Datatransfer compleATSDR - ToxFAQs - Lead (p1 of 11[IMAGE] 

TOXFAQS (TM)

   LEAD
   
April 1993
   

    
_________________________________________________________________

Agency for Toxic Substances and Disease Registry (ATSDR)

   
_________________________________________________________________
   
   This fact sheet answers the most frequently asked health
questions
   about lead. For more information, you may call 404-639-6000.
This
   fact sheet is one in a series of summaries about hazardous
substances
   and their health effects. This information is important
because this
   substance may harm you. The effects of exposure to any
hazardous

-- press pace for next page --2substance depend on the dose, the
duration, how you are exposed,
   personal traits and habits, and whether other chemicals are
present.
    
_________________________________________________________________

   SUMMARY: Exposure to lead happens mostly from breathing
workplace air
   or dust, and eating contaminated foods. Children can be
exposed from
   eating lead-based paint chips, or playing in contaminated
soil. Lead
   can damage the nervous system, kidneys, and the immune
systems. Lead
   has been found in at least 922 of 1,300 National Priorities
List sites
   identified by the Environmental Protection Agency.
    
_________________________________________________________________
     
   What is lead?
   
   (Pronounced led)
   
   Lead is a naturally occurring bluish-gray metal found in small
amounts
   in the earth's crust. It has no special taste or smell. Lead
can be
3found in all parts of our environment. Most of it came from
human
   activities like mining, manufacturing, and the burning of
fossil
   fuels.

   Lead has many different uses, most importantly in the
production of
   batteries. Lead is also in ammunition, metal products (solder
and
   pipes), roofing, and devices to shield x-rays.
   
   Because of health concerns, lead from gasoline, paints and
ceramic  
   products, caulking, and pipe solder has been dramatically
reduced in
   recent years.
   
   What happens to lead when it enters the environment?

     * Lead itself does not break down, but lead compounds are
changed bysunlight, air, and water.
     * When released to the air from industry or burning of
fossil fuelsor waste, it stays in air about 10 days.
     * Most of the lead in soil comes from particles falling out
of the  
       air.
4  * City soils also contain lead from landfills and leaded
paint.
     * Lead sticks to soil particles.
     * It does not move from soil to underground water or
drinking waterunless the water is acidic or "soft".
     * It stays a long time in both soil and water.
   
   How might I be exposed to lead? 

     * Breathing workplace air (lead smelting, refining, and
       manufacturing industries)
     * Eating lead-based paint chips
     * Drinking water that comes from lead pipes or lead soldered
       fittings 
     * Breathing or ingesting contaminated soil, dust, air, or
water near
       waste sites 
     * Breathing tobacco smoke  Eating contaminated food grown on
soil containing lead or food   covered with lead-containing
dustBreathing fumes or ingesting lead from hobbies that use lead
(leaded-glass, ceramics)
5
   How can lead affect my health?
     
   Lead can affect almost every organ and system in your body.
The most
   sensitive is the central nervous system, particularly in
children.
   Lead also damages kidneys and the immune system. The effects
are the
   same whether it is breathed or swallowed.

   Exposure to lead is more dangerous for young and unborn
children.
   Unborn children can be exposed to lead through their mothers.
Harmful
   effects include premature births, smaller babies, decreased
mental
   ability in the infant, learning difficulties, and reduced
growth in
   young children. These effects are more common after exposure
to high
   levels of lead.
   In adults, lead may decrease reaction time, cause weakness in
fingers,
   wrists, or ankles, and possibly affect the memory. Lead may
cause 
   anemia, a disorder of the blood. It can cause abortion and
damage the
   male reproductive system. The connection between these effects
and
   exposure to low levels of lead is uncertain.
6likely is lead to cause cancer?

   The Department of Health and Human Services (DHHS) has
determined that
   lead acetate and lead phosphate may reasonably be anticipated
to be
   carcinogens based on studies in animals. There is inadequate
evidence
   to clearly determine lead's carcinogenicity in humans.

   Is there a medical test to show whether I've been exposed to
lead?
   
   A blood test is available to measure the amount of lead in
your blood
   and to estimate the amount of your exposure to lead. Blood
tests are
   commonly used to screen children for potential chronic lead
poisoning.
   The Centers for Disease Control and Prevention (CDC) considers
   children to have an elevated level of lead if the amount in
the blood
   is at least 10 micrograms per deciliter (10 g/dL). Lead in
teeth and 
   bones can be measured with X-rays, but this test is not as
readily
   available.
   
   Has the federal government made recommendations to protect
human
7health?
   
   The Centers for Disease Control and Prevention (CDC)
recommends all
   children be screened for lead poisoning at least once a year.
This is 
   especially important for children between 6 months and 6 years
old.
   
   The Environmental Protection Agency (EPA) requires lead in air
not to
   exceed 1.5 micrograms per cubic meter (1.5 g/cubic meter
averaged
   over 3 months. The sale of leaded gasoline will be illegal as
of  
   December 31, 1995. EPA limits lead in drinking water to 15
micrograms
   per liter.
   
   The Consumer Product Safety Commission (CPSC), EPA, and the
states
   control the levels of lead in drinking water coolers. Water
coolers
   that release lead must be recalled or repaired. New coolers
must be  
   lead-free. Drinking water in schools must be tested for lead.
   
    The Department of Housing and Urban Development (HUD)
requires that
   federally funded housing and renovations, public housing, and
Indian
   housing be tested for lead-based paint hazards. Hazards must
be fixed
8by covering the paint or removing it.Occupational Safety and
Health Administration (OSHA) limits the
   concentration of lead in workroom air to 50 g/cubic meter for
an
   8-hour workday. If a worker has a blood lead level of 40
g/dL, OSHA
   requires that worker to be removed from the workroom.
   
   Glossary
   
   Carcinogenicity: Ability to cause cancer.
   
   Anemia: Low numbers of red blood cells or hemoglobin.
   
   Ingesting: Taking food or drink into your body.
   
   Microgram (g): One millionth of a gram.

    
   
   References 
9
   Agency for Toxic Substances and Disease Registry (ATSDR).
1993.
   Toxicological profile for lead. Atlanta: U.S. Department of
Health and
   Human Services, Public Health Service.
   
   

   Agency for Toxic Substances and Disease Registry (ATSDR).
1993. Case
   studies in environmental medicine: Lead toxicity. Atlanta:
U.S.
   Department of Health and Human Services, Public Health
Service.

   

   Where can I get more information?

   ATSDR can tell you where to find occupational and
environmental health
   clinics. Their specialists can recognize, evaluate, and treat
   illnesses resulting from exposure to hazardous substances. You
can
   also contact your community or state health or environmental
quality
   department if you have any more questions or concerns. For
more
ATSDR - ToxFAQs - Lead (p10information, contact:
   
   Agency for Toxic Substances and Disease Registry
   
   Division of Toxicology

   1600 Clifton Road NE, Mailstop E-29
   
   Atlanta, GA 30333
   
   Phone: 404-639-6000

   [IMAGE] U.S. Department of Health and Human Services, Public
Health
   Service, Agency for Toxic Substances and Disease Registry

   
    
_________________________________________________________________
   
   Link to ATSDR ToxFAQs MENU
   
 
   1Link to ATSDR Science Corner
    
_________________________________________________________________
   
    Charlie Xintaras / chx1@atsoaa1.em.cdc.gov
   


Command: Use arrow keys to move, '?' for help, 'q' to quit, '<-'
to go back 
   Gettig http://atsdr1.atsdr.cdc.gov:8080/cx.html
Lookup atsdr1.atsdr.ccgov:8080.
Making HTTP connection to atsdr1.atsdr.cdc.gov:8080.
Sending HTP request.
HTTP requestsnt; waiting for response.
Read256 bye of data.of 32486byes of data.
Datatransfercomplete   ATSDR Science Corner (p1 of 45
                            [IMAGE] SCIENCE CORNER

    AGENCY FOR TOXIC SUBSTANCES AND DISEASE REGISTRY
(ATSDR)ATLANTA,
GEORGIA__________________________________________________________
_______HI! WELCOME TO "ATSDR SCIENCE CORNER"



   (NB: You can "Scroll" or "Pg Dn" this document or select a
specific
   item from the MENU. There are "quiklinks" in the document(s)
that
   allow you to return quickly to the MENU.)


-- press pace for next page --2
ATSDR Science Corner MENU
   IntroductionWhat is "ATSDR Science Corner"?
     
   Hazardous Waste Conference(s)Hazardous Waste and Public Health
'93: (Select Papers)

   
          Hazardous Waste: Impact on Human and Ecological Health
          (Atlanta, June '95)

 3Congressional Testimony

Health Impacts of Incineration - Part I


          Health Impacts of Incineration - Part IIATSDR: Public
Health Actios and Findings

   Superfund Sites: Adverse Health ImpactsATSDR: Applied Research

   New Topics/Issues

 4       ToxFAQs (tm) (Quick Guide to Hazardous Substances)Top
20Hazrdous Substances: ATSDR/EPA Priority ListBiennial Report to
Congress: 1991 nd1992 (ExecutiveStatement)ATSDR Board of
Scientific Counselors Annual Report (1994)

   World Wide Web / Mosaic / Search Toolsn Overview ofthe World
Wide Web (WWW)

   Some Useful HTML Documentation

 5A Little About MOSAICFinding New Listings on InternetTools /
Searching for InformationOther On-Line InformationServices

   

   Environmental Health ResourcesNational and Global
Environmental Health Resources

 6Journals / NewslettersSchools of Public HealthDepartments of
Occupational and Environmental Health
   Government Servers (National / International)United States
Public Health Service (PHS ACT of 1944)


          United States Government Servers (Agency / Subject
Index)United Nations

   Special Topics / Issues In Environmental Health
 7Hazardous Waste and Public Health '93: (Select Papers)ATSDR
Biennial Report to Congress: 1991 and 1992 (ExecutiveStatement)

   CreditsAcknowledgements

    
_________________________________________________________________
A LITTLE HISTORY ABOUT "ATSDR SCIENCE CORNER"
   
 8"ATSDR Science Corner" is an HTML (HyperText Markup Language)
document
   (MENU) developed by Dr. Charlie Xintaras, Office of the
Associate
   Administrator for Science, ATSDR, to search the Internet for 
   information resources that are free, in the public domain, and
relate
   to environmental health issues of concern to ATSDR. The
primary focus
   of "ATSDR Science Corner" is to find and share global
information 
   resources on the linkage between human exposure to hazardous
chemicals
   and adverse human health effects. The MENU may be accessed
with NCSA's
   Mosaic or any World-Wide Web Browser that supports the HTML
document
   format.

   The MENU is a simple support tool for use by ATSDR scientists
and
   other researchers searching the Internet for relevant
environmental
   health information. The MENU is dynamic. New environmental
health
   information resources are cited, searched, and documented, as
they
   come on-line. It is a research service provided through the
ATSDR
   World-Wide Web Server. It is a way for ATSDR scientists to
find and
   share information with the public.
   A short description of each data resource is provided to help
you
9decide which data resource you want to access. To reach a
resource,   
   place the cursor over the highlighted hypertext and click
once.  
   
   Give it a try. Share your findings with others!! Keep in mind
that the
   Internet is in a state of flux. If something doesn't work,
have 
   patience. Somebody out there is trying to fix it.
   
    Send us your comments. If you found an address on the
Internet that  
   would be useful to scientists in this field, send it to us
with a   
   brief comment on how you used the information. In this way, we
can
   gradually expand and improve "ATSDR Science Corner".
   
   ATSDR Science Corner MENU
    
_________________________________________________________________
   
   
   
                  AN OVERVIEW OF THE WORLD WIDE WEB (WWW)

   
 
   ATSDR Science Corner (p10
   
     * About the WWW, HyperText, HTTP, and HTML
   
        Good information (illustrated with simple but informative 
       graphics) for the beginner who wants to get started on
theInternet and is a little confused. Topics covered include:
    
       An Overview of World Wide Web, What HyperText is (.gif),
The 
       Popularity of the Web (.gif), What you can get from the
Web   
       (.gif), What HTTP is (.gif), and What HTML is (.gif).

   
     * Entering the World-Wide Web: A Guide to CyberspaceThis is
an in-depth presentation on the WWW and includes anindex/glossary
with hypertext linkages.ATSDR Science Corner
MENU_____________________________________________________________
1               SOME USEFUL HTML DOCUMENTATION
     * A Beginner's Guide to HTMLThis is a primer for producing
documents in HTML, the markuplanguage used by the World Wide Web.
     
     * HTML Quick ReferenceThis document presents a concise
reference guide to Version 1 ofHTML, listing almost all of the
Version 1 elements, and giving abrief description of each one. It
was developed by Michael Grobeof the University of Kansas.
2* HTML HyperEditThis software was developed by Stephen Hancock
(Australia) forMS-Windows (tm) users to aid and assist in the
creation of HTMLdocuments. It includes an excellent walkthrough
on how to use theeditor. What you are reading was created with
this editor.To locate this package, follow these instructions.
You are going
       to use a search routine. It is called Doc Finder. First,
click onHTML HyperEdit. Then, follow instructions until you reach
"Searchthe Server". Enter the word "HyperEdit" in the Search
Index Box.Your search response will contain the entry
"viewers.html." Clickon this. You're almost there. Now, scroll
down until you find
       OTHER UTILITIES /HTML Editors.You will have to download
the file as a ZIP file and thendecompress it (PKUNZIP). 
3IconsThis is a useful listing of icons that you can use in
yourdocuments. You can also find some iconsNational Center
forSupercomputing Applications (NCSA) Mosaic for Microsoft
Windows  file. The file icons at the end of this MENU are from
the Mosaicfile.ATSDR Science Corner MENU
    
_________________________________________________________________ 
                    A LITTLE ABOUT MOSAIC



ATSDR Science Corner (p14 of 45)What is MOSAIC?Mosaic is an
Internet-based global hypermedia browser that allowsyou to
discover, retrieve, and display documents and data from allover
the Internet. Mosaic was developed at the National Center
forSupercomputing Applications at the University of Illinois,
Urbana- Champaign.FINDINGNEW ISTINGSON INTERNETSome key resources
to keep ahead of the game.
5
   Very professional and very timely.
     * NCSA Mosaic "What's New" Page: This is a day-by-day
listing of new information resources on the Internet available
through NCSA Mosaic. This is the best way tokeep up with new
listings.
     * NCSA Doc Finder:

       This is a new Doc Finder service at NCSA. Currently, all
HTML  documents on the NCSA Web server, (ie documents which have
URLshaving the prefix http://www.ncsa.uiuc.edu/...), are
accessibleand searchable through this service. A tutorial for
installing DocFinder is available at this address. You can use
this search tolocate HyperEdit mentioned above.ATSDR Science
Corner MENU
    
6________________________________________________________________
_             TOOLS / SEARCHING FOR INFORMATION

   Getting started is not easy!! Read the information on how to
search
   with Jughead and Veronica.
   See also in this document Other On-Line Information Services.
     * Jughead:(Gopher directory search) Jughead is a database of
Gopher links.It accepts word searches and the search result can
be used toaccess menus on Gophers.
ATSDR Science Corner (p17 of 45)* Veronica:(Gopher directory
search) Veronica is an index and retrievalsystem which can locate
items on most of the Gopher servers on theInternet. Veronica
finds resources by searching for WORDS inTITLES. It does not do a
full text search.ATSDR Science Corner MENUSME ENVIRONMENTAL
HEALTH ESOURCES

     * ERIN (Environmental Resources Information Network):
   The Environmental Resources Information Network (ERIN) is a
8project of the Australian Department of the Environment and
       associated agencies. Information you can find includes
air(weather and climate), land and water, humans and the
environment,life (biodiversity), sea (marine and coastal
environments), stateof the environment, and general information.
Also available is a  Search the ERIN WWW Server. 
_____________________________________________________________

     * NAS (National Academy of Sciences):
     This is the World Wide Web, Gopher, and FTP server of the
NationalAcademy of Sciences (NAS), National Academy of
Engineering (NAE),the Institute of Medicine (IOM), and the
National Research Council(NRC).       

       See especially the What's New at NAS/NAE/IOM/NRC. "Search
allmenus on the server" for quick access to published reports
intoxicology, risk , and environment. Some reports have full
text,
9others have short summaries. The Office of News and
Publicationshas a good summary of press releases, reports and
events guide. 
_____________________________________________________________ 
     * NSF (National Science Foundation):The National Science
Foundation (NSF) is an independent agency ofthe Federal
Government established in 1950. Search the "Database
       of Research Awards" for research supported by the NSF. 
_____________________________________________________________  
     * ATSDR (Agency for Toxic Substances and Disease
Registry):This is the Home Page of the Agency for Toxic
Substances and Disease Registry (ATSDR). Want to learn something
about ATSDR?Mission, goals, programs, activities, people, etc.
20HazDat:This is ATSDR's Hazardous Substance Release/Health
EffectsDatabase. Looking for information on hazardous waste sites
and then some? You're at the right place!!
      
_____________________________________________________________  
     * ATSDR International Congress on Hazardous Waste: Impact on
Humanand Ecological HealthScheduled for June 5-8, 1995, Atlanta,
Georgia, USA. Goodinformation on the upcoming
Congress.________________________________________________________
_____
     * ATSDR Board of Scientific Counselors (BSC):
1Look here for information on the members of the Board
ofScientific Counselors (BSC), Agency for Toxic Substances
andDisease Registry (ATSDR).The ATSDR Board of Scientific
Counselors Annual Report (1994) ishere.The ATSDR Board of
Scientific Counselors MINUTES (April 1994) arehere.

       The ATSDR Bord of Scientific Counselors Annual Report
(1993) ishere. In the Annual Report and MINUTES documents, you
can pick the menutem you want to read. There are "quiklinks" in
these documents to
       help you move around quickly.
     *
        
_____________________________________________________________

2* HyperDOC:Have you tried HyperDOC? This is a
multimedia/hypertext resourceof the U.S. National Library of
Medicine (NLM). You can access easily several on-line information
services. There is NLM, NIH, and the World. This last one is also
called Other BiomedicalOn-Line Information Services. There is a
good section onNavigational Aids. There is also a section on
Specific Sources.   
_____________________________________________________________ 
     * NIH (National Institutes of Health):This is the Home Page
of the National Institutes of Health (NIH). Information and
services provided via this resource include:

          + Molecules R US - an interactive interface to
facilitate   access (browsing, searching and viewing) of the
molecular structure data contained within the Brookhaven Protein
Data
3       Bank (PDB).+ PDB At A Glance - a hypertext catalogue of
the PDB suitable     for browsing purposes. Structures can be
displayed via the      "Molecules R US" interface.   + The NIH
Guide to Molecular Modeling - an illustrated     hypertext-based
primer on molecular modeling methods,       software, and
applications in the biological
sciences.________________________________________________________
_____
     * WHO (World Health Organization):
     This is a Geneva based database for health information. When
youaccess the WHO Home Page, click on "WHO Infoservers.html" and
thenclick on the "WHO Gopher Server." Click again on "WHO Major
Programmes." Look for Promotion of Chemical Safety and
Promotionof Environmental Health. The first entry gives you
information onenvironmental health criteria and chemical safety
news. The secondone has information on three global environmental
health networks,
4including epidemiology, library, and technology.Other WHO Major
Programmes include communicable diseases,essential drugs,
nutrition, AIDS, vaccines, health literature,human reproduction,
statistical information, noncommunicablediseases, strengthening
of health services, health economics,tropical diseases, and
technical terminology service.WHO is also offering a Bulletin
Board System. It is experimentaland an interesting idea. There is
good information about the   system and where it is going. The
first effort will concentrate on
       issues of health futures research. Also planned is a
mechanism forexchanging articles.
     *  
_____________________________________________________________
     * TogetherNet:This is an on-line information and
communication network for use  
5by individuals and organizations working toward a
sustainablefuture for our planet. It is a nonprofit organization.
Scan it andsee what is available.
     *  
_____________________________________________________________
     * EnviroLink:Probably the "largest on-line environmental
information service onthe planet" say the developers, and "some
advanced servicesrequire a password."See also EnviroWeb.
     This is a special project of the EnviroLink Network and
providesinformation on the Virtual Environmental Library, the
       Environmental Education Network, the EnviroForum, and
theEnviroArts Gallery. Also available are two directories,
theInternet Environmental Resources Directory and the
EnviroProducts
6Directory.______________________________________________________
_______
     
     * MOLIS (Minority On- Line Information Service):  This is
the Minority On-Line Information Service (MOLIS) and
hasinformation available in the following areas: minority
institutioninformation, minority institution current events,
searchscholarship and fellowship information, annual federal
plans ofassistance to Historically Black Colleges and
Universities(HBCUs), and the science and engineering alliance.
_____________________________________________________________  
     * CIIT (Chemical Industry Institute of Toxicology): The
Chemical Industry Institute of Toxicology (CIIT) is located in
7the Research Triangle Park, North Carolina and is a
non-profittoxicology research institute. Short summaries of
researchsupported by CIIT are available.   
_____________________________________________________________*
EPA (Environmental Protection Agency):This is a gopher server
developed by the Environmental ProtectionAgency. When you access
this server you will be greeted by an  extensive menu of choices.
You also will be able to get some filesthrough the File Transfer
Protocol (FTP). Good instructions aregiven.Other Environmental
Gophers: When you reach the EPA Home Page ofthe EPA Gopher
Server, click on Other Environmental Information.
       Then click again on Other Environmental Gophers. 

     * 
8 
_____________________________________________________________NTP
(National Toxicology Program):The National Toxicology Program
(NTP) was established in 1978 bythe Secretary of Health and Human
Services to coordinatetoxicology research and testing of
potentially hazardous
       chemicals. The status of all NTP studies is available
through aWAIS search. Abstracts are also available of NTP
reports. 
_____________________________________________________________   
     * ToxFAQs (tm) (Quick Guide to Hazardous Substances)The
factsheets in this file were prepared by the ATSDR Division
ofToxicology and answer the most frequently asked questions about
exposure to hazardous substances and health effects. The
summariesare brief and informative.
     
P9For more information on the health effects of exposure to
specifichazardous substances, see the ATSDR/EPA "Top 20
HazardousSubstances".____________________________________________
_________________
     * Top 20 Hazardous Substances: ATSDR/EPA Priority List:  
"Top 20 Substances" on the ATSDR/EPA Priority List of
HazardousSubstances for 1992, as reported in the ATSDR Biennial
Report toCongress: 1991 and 1992. Each chemical is identified
with a RankNumber and includes an ATSDR Public Health
Statement.CEDR (ComprehensveEpmilogic DataResource): is
Department of Energy (DOE) resource contains much
informationincluding studies at Hanford, Fernald, Mound Facility,
Oak Ridge,Rocky Flats, and Savannah River Plant. Check the CEDR
Catalog for  full list of studies. The principal investigators
are with theLawrence Berkely Laboratory, University of
California.
30The mission of the DOE CEDR Program is "to enhance DOE's
epidemiologic research by facilitating independent research
tovalidate and supplement DOE research on health effects
associatedwith working at or living near facilities involved with
DOE or
       other energy production facilities."ATSDR Science Corner
MENU
    
_________________________________________________________________
OTHER ON-LINE INFORMATION SERVICES
     

    
_________________________________________________________________ 
                         SEARCH SERVERS
 1
   (We have included this list for those who want to explore more
of the
   Internet services. Several resources were suggested by NLM and
ERIN.
   It is not all-inclusive, but will be expanded as the need
arises.)* The Archplx page is a World-Wide Web front-end to
Archie (asystem for locating files on file transfer protocol
(ftp) archivesites).
     
     * The World Wide Web Worm is a catalog of materials found
byexploring the Web with a software automaton.   

     * The Mother-of-all BBS is a registry of Web services.
     
     * Obtain free software via the softsearch
search-and-retrievesystem.

     * The National Center for SuperComputing Applications (NCSA)
offers
2both a set of Internet Starting Points and a Resource
Meta-Index.


     * BOING: This is a search of Bio Oriented INternet Gophers.
   
     * CUI: This is a searchable Index of WWW Sources at the
Centre  Universitaire d'Informatique, University of Geneva
(Switzerland).
     
     * Global Network Navigator Index of Science:

        This server provides a wide array of choices for
accessingscience resources. Over fifteen science categories are
listed.Also has a good Search Index.
     
     * World Wide Web Virtual Library/Biosciences:
     This is an endless list of valuable resources. The author
has donean extensive job tracking the URLs.
     
3* CRISP (NIH Searchabl Gopher Index):This is the searchable
version of the biomedical information
       database on research supported by the Public Health
Service (PHS)and intramural research programs of the National
Institutes of
       Health (NIH) and the Food and Drug Administration
(FDA).The NIH CRISP (Computer Retrieval of Information on
ScientificProjects) provides an abstract for each research grant
funded and
       details to contact the principal investigator. Contains a
goodlisting of biomedical research grants in support of
Superfundresearch.
     * Yahoo - A Guide to the WWW:  

       This resource provides an almost "endless" list of
resources thatare organized in a simple and useful hierarchy.
There is a"search" function available. Also, there is a direct
connection to"WebCrawler" and other search engines for additional
searchcapability.
Ente a datbase searchstring: athersclerosis
Getinggopher://gopher.nih.gov/77/gopherlib/indices/crisp/index
Lookup gopher.ni.gov.
Making Goher connection to gopher.nih.gov.
Sending Gopher request.
Gopher requestsnt; waiting for response.
   Select one of:
(FILE) R01HL42392 WEINBERGER, JUDAH Z CELLULAR METABOLISM IN
RESPONSE TO HY -PROJECT NUMBER..

     

This is a sarchableindex. Use's' to search 
Gettinggophe://gopher.nih.gov/0R127529303-127533647-/gopherlib/da
ta/crisp/FebHLookup gopher.ni.gov.
Making Goher connection to gopher.nih.gov.
Sending Gopher request.
Gopher requestsnt; waiting for response.
Read 82 byt of data.
338 bytes of data.
4178
430
Datatransfer complete  R01HL42392       WEINBERGER, JUDAH Z      
CELLULAR METABOLISM IN RES (p1 of
5)---------------------------------------------------------------
-----------------
R01HL42392       WEINBERGER, JUDAH Z       CELLULAR METABOLISM IN
RESPONSE TO HY
-PROJECT NUMBER......5 R01 HL42392-05FY  93    WEINBERGER, JUDAH
Z
IRG/INTRAMURAL UNIT..METCOLUMBIA UNIVERSITY
AWARD AMOUNT.........   $184,159630 WEST 168TH STNEW YORK, NY 
10032
PERFORMING ORGANIZATION: COLUMBIA UNIVERSITY NEW YORK
TITLE   CELLULAR METABOLISM IN RESPONSE TO HYPERCHOLESTEROLEMIA

ABSTRACT:

Atherosclerotic disease is the predominant underlying organic
disorder leading to myocardial infarction, stroke, and peripheral
vascular disease.  Increased levels of serum cholesterol is a
major
risk factor for the development of atherosclerosis.  The primary
form of circulating cholesterol has been defined in recent years.

 
-- press pace for next page --2
Intracellular cholesterol content is regulated by integration of
two pathways that govern the supply of extracellular and
endogenous
cholesterol. Cells depleted of cholesterol increase their LDL
receptor numbers and increase the activity of cholesterol
biosynthetic enzymes.  As cholesterol builds up in the cell, LDL
receptor number and enzyme activities of a number of cholesterol
biosynthetic enzymes are downregulated.  The decrease in LDL
receptor number, and in activity of a rate-limiting cholesterol   
biosynthetic enzyme.  HMG-CoAreductase, is controlled, in part,
by
repression of transcription of these genes.  The experiments 
proposed are designed to elucidate the nature of the cellular
factors which interact with specific DNA elements to repress   
transcription of these genes in states of cholesterol abundance.
Using DNA fragments from previously identified sterol response
elements, gel mobilitiy shift analysis will be performed in
nuclear
and whole cell extracts from sterol-starved cells and from cells
grown in abundant sterols.  Site directed mutagenesis of the
sterol
response element(s) will be performed to correlate the binding
activity in vitro and activity as a repressor element in vivo.  
This will be correlated with in vivo occupancy of specific DNA   
3
binding sites by in vivo methylation protection.  With rapid
sensitive assays developed for detection of this trans-acting
factor(s), it will be possible to characterize the biochemical
nature of the protein, and the clone the cDNA encoding this
protein(s).  This will allow structural and functional analysis
of
the mechanism of action of this important transcription
regulatory
factor.  The developmental control of the activity of this  
repressive factor will be examined.  A search will be made for 
related transcriptional factors.  An analysis of the steric
constraints on action of the sterol repressive factor will be
undertaken, in order to better understand the requirements for
protein-protein interaction intranscriptional regulation.  Mutant
cell lines will derived in order to identify genes whose products
participate in sterol mediated gene repression.  Later studies
will
seek to examine the dynamics of sterol repression by an
identified 
factor(s) in metabolic states leading to elevated serum
cholesterol
such as hyperthroidism and diabetes.  Further insight developed
from these experiments into the normal process of receptor
regulation will allow the design of new strategies to reverse 
hypercholesterolemia and diabetes.  Further insight developed
from
4
these experiments into the normal process of receptor regulation
will allow the design of new strategies to reverse
hypercholesterolemia and prevent athersclerosis.

CRISP INDEXING TERMS FROM CRISP THESAURUS:
06584141P   cholesterol 
09444896P   cellular pathology
10363611P   enzyme induction /repression
12584102P   genetic transcription 
17441643P   hypercholesterolemia
27912343P   steroid metabolism 
06292343S   chemical binding
12577133S   genetic promoter element
12584500S   transcription factor
17492258S   low density lipoprotein
21028337S   nucleic acid sequence
21744593S   HMG coA reductase
24465000S   DNA binding protein 
25731000S   receptor
27937670S   steroid biosynthesis
5
06036055T   flow cytometry 
12554314T   molecular cloning
12599080T   point mutation
21028289T   DNA footprinting
24461900T   protein purification
29355444T   tissue /cell culture
.

Command: Use arrow keys to move, '?' for help, 'q' to quit, '<-'
to go back
Gettig
gophr://gophr.nih.g/77/gophelib/indices/crisp/index?ahersclerosis
G

   Select one of:

(FILE) R01HL42392 WEINBERGER, JUDAH Z CELLULAR METABOLISM IN
RESPONSE TO HY -PROJECT NUMBER..


 
This isa seachable index.  Use 's' to search  Enter adatabase
search string: rdi and selenium
Getinggopher://gopher.nih.gov/77/gopherlib/indices/crisp/index?at
hersclerosisGLookup gopher.ni.gov.
Making Goher connection to gopher.nih.gov.
Sending Gopher request.
Gopher requestsnt; waiting for response.


 
This is a sarchableindex. Use's' to search
Enter adatabase search string: rdi
Getinggopher://gopher.nih.gov/77/gopherlib/indices/crisp/index?rd
i+and+seleniILookup gopher.ni.gov.
Making Goher connection to gopher.nih.gov.
Sending Gopher request.
Gopher requestsnt; waiting for response.(FILE) P50HL422150006 VAN
LUNTEREN, ERIK SCOR IN CARDIOPULMONARY DISORDERS OF -PROJECT
NUMBER...

 
This is a sarchableindex. Use's' to search
Gettinggophe://gopher.nih.gov/0R127268860-127272652-/gopherlib/da
ta/crisp/FebHLookup gopher.ni.gov.
Making Goher connection to gopher.nih.gov.
Sending Gopher request.
Gopher requestsnt; waiting for response.
Read 82 byt of data.
338 bytes of data.
594
850
116 bytes of data.
618
2386
3869
Datatransfer complete  P50HL422150006   VAN LUNTEREN, ERIKSCOR IN
CARDIOPULMONARY DI (p1 of
4)---------------------------------------------------------------
-----------------
P50HL422150006   VAN LUNTEREN, ERIK        SCOR IN
CARDIOPULMONARY DISORDERS OF-PROJECT NUMBER......5 P50 HL42215-07 
   SUB: 0006FY  94    VAN LUNTEREN, ERIK
IRG/INTRAMURAL UNIT..ZHL1UNIV HOSPITALS
AWARD AMOUNT.........   $143,8932074 ABINGTON ROADCLEVELAND, OH 
44106-4389
PERFORMING ORGANIZATION: CASE WESTERN RESERVE UNIVERSITY
TITLE   SCOR IN CARDIOPULMONARY DISORDERS OF SLEEP
  SUB TITLE REGULATION OF PHARYNGEAL MUSCLE CONTRACTION

ABSTRACT:

Frequent sleep-related respiratory disturbances (SRRD) have been
recognized to occur in as many as 70% of elderly and 15% of
middle-aged
subjects.  Although it is widely agreed that subjects with
obvious
daytime sleepiness that occurs in association with severe
obstructive
sleep apnea (Respiratory disturbance indices (RDI) >30) benefit
from

 
-- press pace for next page --2
treatment of their sleep disorders; there is no consensus (and a
paucity
of data) regarding treatment benefits in subjects with a less
profound
disorder.  Rational utilization of health care resources for
diagnosis
and treatment of sleep apnea requires assessment of whether
adverse
health effects occur as a consequence of mild or moderate levels
of SRRD,
and whether any such health effects may be reversible with
treatment.
In this study, we propose to determine the degree to which neuro-
psychological performance and general health status and function
may be
impaired in subjects with mild and moderate degrees of SRRD, as
compared
to subjects with minimal apneic activity.  The degree to which
improvement may occur following specific treatment will also be
assessed.
We propose to assess neuropsychological performance, sleepiness
and
general functional status in 330 subjects, including subjects
with little
apneic activity (RDI<5), mild activity (RDI 5-14), and moderate
activity
(RDI 15-25).  Of these subjects, 75% will be selected from a
clinic-based
sample, and 25% will be recruited from an ongoing
population-based study.
150 subjects with mild and moderate activity will be randomized
to
receive "conservative" medical therapy (CMT) or CMT plus nasal
CPAP
therapy.  We will utilize simple statistics, as well as
multivariate 
techniques, to determine the relationship between SRRD (and
associated
3
hypoxemia, sleep fragmentation, and physiological sleepiness) to:
a)
intellectual abilities, attention and vigilance, psychomotor
performance,
learning and memory, and executive functions, and b) to general
health
status and function.  Potential benefits of treatment specific
for sleep
apnea in subjects with mild and moderate SRRD will also be
determined
after two months of CPAP therapy.  These data will provide new
information about the health effects of mild and moderate sleep
apnea
that are needed for appropriate clinical decision making and
utilization
of health care resources. 

CRISP INDEXING TERMS FROM CRISP THESAURUS:
20567094P   sleep disorder
24835397P   neuropsychology
24843472P   psychomotor function
40000187P   functional ability
40030054P   sleep apnea 
09444477S   disease proneness /risk 
20426116S   nervous disorder chemotherapy
20426433S   nervous disorder diagnosis
20426438S   nervous disorder epidemiology 
4
23834396S   longitudinal human study
24821617S   attention
24822652S   wakefulness
24831070S   cognition 
24832589S   emotion
24832687S   anxiety 
24832785S   depression
24834058S   learning
24834698S   memory
24835482S   performance
24835629S   intelligence
25988475S   respiratory disorder epidemiology
26028512S   respiratory airway pressure
28941596S   human therapy evaluation
14652234T   human subject
24835410T   neuropsychological test
.



Command: Use arrow keys to move, '?' for help, 'q' to quit, '<-'
to go back
Gettig gophr://gophr.nih.g/77/gophelib/indices/crisp/index?rdi

   Select one of:

(FILE) P50HL422150006 VAN LUNTEREN, ERIK SCOR IN CARDIOPULMONARY
DISORDERS OF -PROJECT NUMBER...  


This isa seachable index.  Use 's' to search Enter adatabase
search string: intelligence
Getinggopher://gopher.nih.gov/77/gopherlib/indices/crisp/index?rd
i
Lookup gopher.ni.gov.
Making Goher connection to gopher.nih.gov.
Sending Gopher request.
Gopher requestsnt; waiting for response.
Transfered 1155 bytes231434654620578769568125929410463
bytes161627573898504762027357851296672082219773132428754426597775
289073006212172372(p1 of 21)R01AG07137 MC ARDLE, J JACK GROWTH
UVESOF ADULT INTELLIGENCE B -PROJECT NUMBER..
(FILE) R01HL33041 LONG, WILLIAM J ARTIFICIAL INTELLIGENCE AND
CARDIOVAS -PROJECT NUMBER..
(FILE) S06GM081920018 BRADEN, JEFFERY P INTERDISCIPLINARY
BIOMEDICAL RESEARCH -PROJECT NUMBER..
(FILE) R29HD29751 CONNERS, FRANCES A PHONOLOGICAL PROCESSING AND
MENTAL RE -PROJECT NUMBER..
(FILE) R01DK43725 HAGEN, JOHN W COGNITIVE STRATEGY PROCESSES IN
DIABE -PROJECT
NUMBER..
(FILE) R01HD22839 CECI, STEPHEN J CONTEXTUAL CONSTRAINTS ON
INTELLECTUA -PROJECT NUMBER..
(FILE) R01AA01455 STREISSGUTH, ANN P ALCOHOL INTAKE DURING
PREGNANCY--OFFS -PROJECT NUMBER..
(FILE) R01AG04337 CUNNINGHAM, WALTER R AGE CHANGES IN
INTELLECTUAL ABILITIES -PROJECT NUMBER..
(FILE) R03AG11999 ALEXANDER, JANICE D LITERACY AND HEALTH CARE
UTILIZATION -PRO
--More--  This isa sarchable index.  Use 's' to search  2
JECT NUMBER...
(FILE) R01DA04965 HURT, HALLAM MATERNAL COCAINE USE--LONG-TERM
EFFEC -PROJECT NUMBER..PHD30080041 ZIGLER,EDWARD F MENTAL
RETARDTIONAD DEVELOPMENTAL -PROJECT NUMBER...PD218870001 FELTON,
REBECCA H NEUROBEHAVIORAL DEFINITION AND SUBTYP -PROJECT
NUMBER..Z1MH263 KLIMES-OUGAN, B INTELLECTUAL OMPETENCE AND
PSYCHOPAT -PROJECT NUMBER..Z01MH02644ZAH-WAXLE,  DETERRETS TO
PROBLEM AGGRESSION--PRO -PROJECT NUMBER..ZNS0246NELSON, K
BPHENOBARBITAL CLINICAL TRIALS IN CHL -PROJECT NUMBER.. 
37AG03055ELIAS, MRRILL F AGE, HYPERTEION ANDITELLCTIVE PE
-PROJECT NUMBER.G764FISK, ARTHURD AUTOMATIC AND CONTROLLED
PROCESSING A -PROJECT NUMBER..10569ZELINSKI, ELIZABTH M
LONGITUDINAL ASSESSMN OFCOGNON.1CA572NATHWANI, BHRAT N CNICL
TRIALS OF EXPETSYSTEM ON L
3 874FRIED, PETERA PRETAL NABI AND CIGARETT CONSE -PROJECT
NUMBER..RDA73 DORFMAN, DAVI HIVINFCEDIVDU'S--CGNITIVE TSTIN
-PROJECT NUMBER..RDC00612 TOMBLIN, JAMES B GENETIC EPIDEMIOLOGYOF
SPECFIC LANG -PROJECT NUMBER..RDC0969STEFANATS, GERRY A
NEUROPHYSIOLOGICAL STUDIES OF LANGUAG -PROJECT
NUMBER..N44DK3268MOSER, JAMESVOICE-DIVENENDOSCOPICREPORTING DAT
-PROJECT NUMBER..  PE1560001 DIETRICH, KIM N HEALTH EFFETSOF LEAD
ON CHILD DEVL -PROJCT NUMBER..N43ES3104BHANDARI, J C INTELLIGENT
TOXICOLOGY PREDICTION SYS-PROJECT NUMBER..   N43ES31005GOMBAR,
VIJAY K COMPUERSSISTED METHODS IN PREDICTI -PROJECT
NUMBER.N43ES31006BHANDARJC NEURALNETWORK-BASED TOXICITY PREDICT
-PROJECT NUMBR..N43ES3007DIMAYUGAMARIO ORGAN-SPECIFIC TOXICITY OF
CHEMICALS -PROJECT


 4
 NUMBER...   HD21056EYMANRICHARDK LIFE EXPECTNCYOF MENTLLY
RETARDD -PROJECT NUMBER..HD2340WAGNER, RICHARD K READING-RELATED
PHONOLOGCAL PROCESSE -PROJECT NUMBER..HD26456BRKOWSKI, JOHN G
PRCURSORS OF RETARDATION IN CHIDREN -PROJECT NUMBER.HD28102HAIER,
RICHARD J REGIONAL CEREBRAL GLUCOSE MTABOLIC R -PROJECT NUMBER..  
R01HD28172FRANCIS, DAVID J DETECTIG READING PROBLEMS BYMODELIN
-PROJECT NUMBER..RHD2910 ADAMS, JANE ISOTRETINOIN
TERATOGENICITY--OUTCOME -PROJECTNUMBER...R01HD0580ZIGLER, EDWARD
F CHILDREN'S AFTER-SCHOOL ARRANGEMENTS -PROJECT
NUMBER...R01HL4786NEWUGER, JANEW INFANTHEART SURGRY--CNS SEQUELAE
OF -PROJECT NUMBER..R01H06740CLRKE, JOHNR TESTIG A DECISIONAID
FOR THE MANAGE -PROJECT NUMBER..R01LM04692EZQUERRNOBERTO F
KNOWLEDGE-BASED SSTEM FOR RDIAC IM -P 5
ROJECT NUMBER..29LM0526SONNENBERG, FRANK A INTELLIGET DECISION
SYSTEM FOR LUNG -PROJECT NUMBER...P4LM05050001 SHORTLIFFE,EDWAR H
CENTER FOR ADVANCED MEDICAL INFORMATI -PROJECT
NUMBER..LM05324PATIL, RAMESH SCLINIAL MANAGEMEN OF CRITICAL ILNE
-PROJECT NUMBER..  29LM05647LEHMANN, HAROLD P FORMALIZING THE
NOTION OF CLINICALSI -PROJECT NUMBER.13LM05768ALTMAN, RUSS
BINTLLIGETSYSTEMSFOR MOLECULAR BIO -PROJECT NUMBER.. 
NLM301IRONROBRT GRATEFUL MED SOFTWARE DEVELPMENT & M -PROJECT
NUMBER..NLM2302EDER, WARREN GRATEFU MD OFTWAE DEVEOPMENT & M
-PROJECT NUMBER..MH085ANDREASNNCY C BRINIMGING IN THE MAJOR
PSYCHOSES.MH42181BARKLY, RUSSELL A ADULTOUTCOME OF ADHD
CHILDRE--SOC-P -PROJECT NUMBER..PMH469810002 CANTWELL, DENNISP
FAMILY STUDIES OF CHILDHOOD PSYHATR  ) 6
-PROJECT NUMBER..MH4812PEARSON, DEBOH A ATTENTION DEFICIT
IMENALLY ETARD
  R0MH49223 LADD, GARY W RISK & PROTETIV FACTORS I ARLY S
-PROJECT NUMBE..MH4981OLDS, DAVID LPRENATAL-EARLY INFACY
PROJECT--AFO -PROJECT NUMBER..  01MH4946WIDOM, CATHY S LONG TERM
METAL OUTCOMESHLD B-PROJECT NUMBER..   01MH49550MILLERWALDENS
NUROPSYCHOLOGICAL TEST NORMS -PROJECT NUMBER......5
R0R29MH51918YURGELUN-TODD, DEBORAHA PROTON SPCTROSCY AND IAGING
IN SC -PROJECT NUMBER..RNS5243SIGMAN, MARIAN D OBJECTS CONCEPTS
IN AUTISTIC CHILDREN -PROJECT NUMBER..NS2671LEVINE, SUSAN 
NEURO-COGNITIVE EFFECTSOF EARLY UNIL -PROJECT NUMBER..  
NS2863OLNESS, KAREN N NEURODEVELOPMENTAL STATUS IN HIV+ UGA
ROJECT NUMBER..   RNS29462 EWING-COBBS, LINDA ACCIDENTALAND
NONACCIDENTAL PEDIATRI -PO ) 7
JECT NUMBER..01NS29857ROSS, JUDITH L ESTROGEN EFFECTS ON COGNITIO
IN TUN -PROJECT NUMBER..O02740VENKATASUBRAMANIAN,VENKA APPLICTIN
OF NUALNETWOKS FOR PR -PROJECT NUMBER..MRR000460383 STABLER, BRIA
GENERL CLICAL RESEARH CENTER....5RR06235KULIKOWSKI, CASIMIRA
UTGRS KNWLEDG-BASED BIOMEDICAL IM -PROJECT NUMBER..S10RR0646DE
CLARIS, NICHOLAS MEDICAL INFORMATIC NETWORK-A DISRI -PROJECT
NUMBER..Z01CM07349WEINSTEIN, J NNW STRATEGIES FOR DRUG
DISCOVERYAND -PROJECT NUMBER..ZMH00508MRSKYA F NEUROPSYCHOLOGICAL
EVALUATION OF PSYC -PROJECT NUMBER..Z0215ALKO, D L MEMORY STRAGE
N NURAL NETWRKS -PROJECTNUMBER......AA06203BAUR, RUSSLL M
PSYCHOPHYSIOLOGY OF IMPLICIT MEMORY I -PROJECT
NUMBER.PAA072030001 PERRINEMERVYN W PSYCHOBIOLOGICAL STUDIES OF
ALCOHOL T -


 8
PROJECT NUMBER..AA10288HEELBROCK,VICTO M PHNOTYPES OF ALCOHOLISM
AMONGNATIV -PROJECT NUMBER..AA10289YATES, WILLIAM R PREDICTORS OF
ALCOHOLISM RELPSE IN A -PRJECT NUMBER..P50AG5133014WEBSTCHARLES W
ALZHEIMERS DISASE RESEARCH -PROJECT NUMBER.5 P50P50AG51420010
DEFIGUEIREDO, UIJ ADRC COSORTIUM OF LOS ANGLES AND OR -PROJECT
NUMBER..R01AG7607BLANCHARD-FIELDS, FREDA TTRIBUTIONAL PROCESSES
IN ADULTHOOD -PROJECT NUMBER...RAG8235HULTCH, DAVIDF INDIVIDUAL
DIFERENCES N MEMORY CHAN -PROJECT NUMBER..P50AG8729001
MAYEUX,RICHARD P AZHEIMERS DISEASE RESEARCHCENTER -PROJECT
NUMBER.....R37AG8937HEYMAN, ABERT DIFFERENCS IN PREVALENCE
ANDINCIDN -PROJCT NUMBER..G9LBOUVIE-VIF,GISELA COGNITIVE EMTIONA
MAURITY IN ADULT -PROJECT NUMBER..R29G982 ALLEN, PHILIP A
ADULTAGE DIFFERENCES IN COGNITIVE NO -PROJEC 9
T NUMBER..G09399GROSMAN, MURRAY CONGNITIVE PROFILES IN ALZHEIMERS
DIS -PROJECT NUMBER..G0943SILVERMAN, WYNE AGNG AND MENTAL
RETARDATION--CHANGES -PROJECT NUMBER..01946602GARILI, JOHN
DANTOMIC, PHYSOLOGIC AND COGNITIVE P -PROJCT NUMBER.. R019936
HORN, JOHN L CAUSES N ADULTDEVELOPMENT OF DIFFER -PROJECT
NUMBER..299976JOHSON, MITZI M AGE IFFERENCES N DECISION MAKINGPE
-PRJECT NUMBER..110RAZ, NAFTALI NEURAL CORRELATES OF AGE-RELATED
DIFF -PROJECT NUMBER..R431238 SCHWARTZ, MAK  COMUTER TOOLS FOR
OUTCOM NALYSIS -PROJECT NUMBER...0312791KIM, LINDA Y LONGITUDIAL
ANALYSIS OF ONTRAST SEN -PROJECT NUMBER..  UI256170004 STEPHENS,
EDWARD DRU DISCOVRY GROUPFOR THE TREATMEN -PROJECT NUMBER.
U01I315410007 HOMER, CHARLES J MOLCULAR BASIS OF IMMUE FUNCTION
IN -P (p10
ROJECT NUMBER..44I3414RAMO, SCOTT L MYBACTERIAINDENTIFICATION BY
HPLC -PROJECT NUMBER...  43R43045KAUFMAN, JONTHAN J ULTRASONIC
ASSESSMENT OF BONE USING N -PROJECT NUMBER.CA11385PETT, PAULA
LTREATMENT OF CANCER WTH HEAVY CHARG-PROJECT NUMBER..  CA2480DI,
KUNIORADIOGRAPHIC IMAGING FOR CACER DIAGN -PROJECT NUMBER.. 
01CA25644KLLMAPEERATHORETICAL STUDES OF DRUG-NUCLEIC
APCA30195CHAMNESS, GARY C MEDICAL ONCOLOGYPROGAM PROJECT--THE
-PROJECT NUMBER..P01CA301950013 MCGUIRE, WILLIA L MEDICA ONCOLGY
PROGRM PROJECT--TH -PROJECT NUMBER..P1CA30159003 CARK,GARY M
MECOCOLOGYPROGRAM PROJECT-THE -PROJECT NUMBER..PCA301959CLARK,
GARY M MEDICALONCOLOGY PROGRAM POJECT--THE -PROJECT NUMBER..  
PCA019595MCGUIRE, WILIAML MDICLONCOLOGYPROGRAM PROJECT--THE 1
-PROJECT NUMBER..P01CA059006 CIOCA, DANIEL R MEDICL ONCOLOGY
PROGRAM PROJECT--TH -PROJECT NUMBER..01CA397COPELD, DONNA
RNEROPSYCHOLOGICAL ASSESSMENT OF CHIL-PROJECT NUMBER..  R33922
ROEMER, ROBERT BULASOUND HYPERTHERMIA SYSTM FOR CA -PROJECT
NUMBER..  43133HUTCHINSON, MARTHA L CONTEXT INFORMATION IN
AUTOMATED CERV -PROJECT NUMBER..P500870002 ABRAMS, DAVID B
ACCELERATING THEPROCESS OF CHANGEFO -PROJECT NUMBER..50870003
GOLDSTEIN,MICHAEL GACEERATING THECSS OF CHANGE FO -PROJCT
NUMBER..508705PROCHASKA, JAMESOACCELERATING THECESSOF CHANGE
FO508706RUGGIERO, LAURI ACELERATIN THE POCESS OF CHANGFO -PROJECT
NUMBER..50872ABRAMS, DAVIDB ACEERATING THE PROCESS F HANGE FO
-PROJECT NUMBER..R52709 MEYER, CHARLES R COPUTED 3D SURFACE AND
VLUMEESTIMA PROJE 2
CT NUMBER..5282305ROSE, JOSEPH DEVLOPING OF ULTRASONIC TISSUE
HARA -PROJECT NUMBER..  P51410003 NODINE, CALVIN F MDELING AND
EVALUATING IMAGEMANAGEM -PROJECT NUMBER..555O'DONNELL, MICHAEL E
BICHEMICAL ACTION OF EBNA1 NEBV RE -PROJECT
NUMBER..355877BARTELS, PETER H KNOWLEDG BASED SYSEMSFOR DIAGNOSTI
-PROJECT NUMBER..R44397 GOLD, OBERT PROGRAM PLANNING AND
EVALUTION EXPERT -PROJECT NUMBER..R4356 LEWITT, ROBERT
DIGITALIMAGE EPRESENTATIONS FOR TOM -PROJECT NUMBR..R4518
SALZMAN, GARY C FLOWCYTOMTRY DATAANALYSIS BYEXPER -PROJECT
NUMBER..R446263 WRIGHT, MICHAE P COMPUTR EDUCATION AND
RIKASSESSMEN-PROJECT NUMBER..   R6319 CARPENTER, JOHN T, JR ANCER
LINKAGINITIATIVE-PROJCT NUMBER......5 R01 CA446511PRESTON,
KENDALL, JR LTRAFAST MORPHOLOGY WORKSTATION FOR -PR ) 3
OJECT NUMBER...R448117 RUSSELL, CHANNING H AIDS FOR GEOGRAPHIC
PATTERN RCOGNITI -PROJECT NUMBER.90172MHA, RADHE 3D
CONFORMALRAIATION HERAPY -PROJECT NUMBER......5 PP90170003
KUTCHER, GERAD J 3D CONFORMAL RADIATION THERAPY -PROJECT
NUMBER......5 P019412MEYER, CHARLSRVALIDATION OF
AUTOMATICSEGMENTATION -PROJECT NUMBER.P019820001 MC SHAN,DANIEL L
OPTIMIZATION OF HIGH DOSE CONFOMAL -PROJECT NUMBER..P98270002
FRAASS, BENEDICK A OPTIMIZATION OF HIGH DOSE CONFORMAL T -PROJECT
NUMBER..P98270003 TE HAKEN, RANDALL K OPIMIZION OF HGH DOSE
CONFOMAL -PROJECT NUMBER..362630BEHLENFREDERICKM COMPUTER
ASSISTED QUANTITATION OF TUM -PROJECT NUMBER..4362795BHANDARI, J
C EURAL SYSTEMSTHAT EXTRAC INFORMATI -PROJECT NUMBER36286CHIEN,
MINZE V CONSULTAION YSTEM FR LUNG NODULE D -PROJECT  4
 NUMBER..36285KORNJIM HYPERMEDA INTELLIGENT BREAST CANCE -PROJECT
NUMBR...R4363994 CHIEN, MINZE V AN EXPERT-TRINED CONSULTATION
SYSTEM -PROJECT NUMBER.  R465 LEE, YUUN ADVANCED NEURAL NETWORK
PATIENT RISK -ROJECT NUMBER...46508GUSTAFSON, DAVIDH ENHNCEMENTOF
COMPUTER SUPPOR IBR -PROJECT NUMBER..R4365146 DONNELL, DEBORH J
INTELLGENT TUTORING SYSTEM FOR MEDIC -PROJECT NUMBER..   R4365184
ROTHBERG, JONATHAN MHIGH RESOLUTION DIFFERENTIATI GENE -PROJECT
NUMBER...  R4365233 JI,QIANG CLASSIFYING CERVIX TSSUE PATTERNS WI
-PROJECT NUMBER..525GALAT, STEPHEN I EXELAR-BED MICAL EXT
CLASSIFIC -PROJECT NUMBER. 533HUNTER, ROBERT M INTERACIVEWELLNSS
SOFTWARE FOR ADU -PROJECT NUMBER..4E0002FRASER, ROBRTB
COMPUTER-ASIDTRAUMA MAAGEMNTI -PROJE5
CT NUMBER..N01M47002MSS, HOWARDNEUROPSYCHOLOGICAL TESTING FOR
CHILDR -PROJECT NUMBERN4N15402SCHIMKE, JOL T ONCOLOGIC P
INSTRUCTIONAL & ADVISO -PROJECT NUMBER.N3O3365VITH, RICHAR H
MOBIL ACCESS T MEDICAL DATA--THE WI -PROJECT
NUMBER..N4O3371SHERERTZ, DAVID VOICE REOGNIININTERFACE AND
KNOWL-PROJECT NUMBER..   N4O40550SHERRTZ, DAVID MOBLE WIRELESS
ACCESS TO KNOWLEDGE -PROJECT NUMBER....   K02D0039HSER, YIH-ING
DRUGABUSE--EPIDEMIOLOGY TRATMENT PR -PROJECT
NUMBER..01D03988BLOCK, ROBERT I EFFECTS OF CHRONIC DRUG USE ON
COGNIT -PROJECT NUMBER..01D006REINISCH, JUNE MSOCIAL DEVIANC &
DRUG ABUSE--EFFECTS -PROJECT NUMBER..  01D0854EYLER, FONDA
DCOCAINE ABUSIN TH RURAL ENVIRONMEN -PROJECT NUMBER.. 
01DA6597SATZ, PAUL NEUROBEHAVIORAL FACTORSIN BLCK MEN -PROJECT
NUMB6
ER...RDA0675TARTER, RLPH  NEUROPSYCHOLOGIC ASESSMENT--CHRONIC
-PROJECT NUMBER...R01DA0721WEISSMAN, MYRNAM OPIATE ADDCTS
CHILDREN-PSYCHOPATHLO -PROJECT NUMBER..U01DA0747SHORTY, VERNONNEW
ORANS COOP AGREMENTFOR AIDS C -PROJECT NUMBER.. 
R01DA07612HEAGAYMRGARET NUODEVELOPMENT OF CHILDRENEXPOSED
-PROJECT NUMBER...P50DA076990001 HSERYIH-ING UCACENTER ON
TRATMENT CARERS (CTC -PROJECT NUMBER..R18393STRICKLAND, TONY
LNEROBEHAVIORAL FUNCION AMONG COCAIN -PROJECT
NUMBER..8524DELANEY-BLACK, VIRGINIAPRENATAL OCAINE-ALCHOL
EXPOSURE--AG -PROJCT NUMBER..9447TSUANG, MING TTWIN STUDY OF
CONSEQUENCES OF DRUG AB -PROJECT NUMBER..  PC02200005
ICHMAN,ROBERT A THE UNY UPSTATE CINICAL SLL RESEA -PROJECT
NUMBER..C0319KENTRYMOD D INTELLIGIBILITY ASESSMENT IN DYSATH
-PROJEC


 7
T NUMBER..C037LOVELAND, KATHRINE A COMMUNICATION IN
AUTISM--PRAGMATIC D -PROJECT NUMBER..C0458LONARD, LAUENCEB
MORPHOLOGICAL DEFICITS IN SPECIFIC LA -PROJECT
NUMBER..RC096RIBERG, LAWRECED DVELOPMENTL PHONOLOGICAL ISORDES
-PROJECT NUMBER...C0559SMITH, ANNE PHYSIOLOGICAL CORRELATES OF
STUTTRIN -PROJECT NUMBER..R44C0758 HERTZ, SUSAN R CUSTOMIZED
SYNTHETIC VOICESFO SPEEC -PROJECT NUMBER..   C1234TAGER-FLUSBERG,
HELEN B LANGUAGE DEICI AD ETAL STATE KN
 -PROJECT NUMBER..P50C12899001 TRAUNER, DORS ORGINS OF
COMMUNICATION DISORDERS -PROJECT NUMBR.....P50C12899002
WOLFECK,BEVERLY ORIGINSOF COMMUICATION DISORDERS -PROJECT
NUMBER.....R29144 QI,YNGYOGANALYSISANDIMPROVEMEN OF ALARYNGEA
-PROJECTNUMBER.. 1535FARLEY, GLENRNEURA CONTROL OF THE LARYNX
-PROJECTNUMBER. 8
.....5 01291649MILOSKY, LINDA M ONLITERAL COMPREHENSION N
LANGUAGE- -PROJECT NUMBER..184TALLL, PAULA A TWIN AND FAMILY GENT
STUDIE OF LA -PROJECT NUMBER..291858DOLLAGHAN, CHISTINEA SPOKEN
WORDRECOGNITON IN LANGUAGEI -PROJECT NUMBER..P30E97379002 BORN,
DAVID MINNESOTALINICL DENTAL RESARCH CE -PROJECT
NUMBER..E9906WRIGLEY, CHARLES NEW STORAGE POSPHOR MAGING MEDIA FO
-PROJECT NUMBER..3E10878BENN, DOGLAS KRO OFKNOWLEDGE IN AUOMATIC
DIGITA -PROJECT NUMBR..R01K17593 TEWARSON, EGINALDP NUMERICAL
SOLTON OF RENAL TRANSPOT -PROJECT NUMBER..R43K48578 ROSEN, DAVIDI
SMARTHOLMUMLASER FOR ENDOSCOPC LI -PROJECT NUMBER..01ES36GRAZIAO,
JOSEPH H ENVIRONMENTAL LAD, REPRODUCTION, AND -PROJECT
NUMBER..P42ES46990005 HAMMOCK, BUC D BIOMARKERS OF EXPOSURE TO
HAZARDOUS S -P 9
ROJECT NUMBER..01ES5015NEEDLEMAN, HERBERT L ATENTION DEFICIT,
SCHOO DYSFUNCTION -PROJECT NUMBER..ES5483JCOBSON, JOSEPH L
HUMANPCB EXPOSURE--CONGENRS &DEVEL -PROJECT NUMBER..44ES572LATS,
HARRY L COLOR-BAED AUTOMATED MICRONUCLEUSSY -PROJECT
NUMBR..R01ES6475 ANGER, WYNHAM K LIKING HUMA ANDANIMNUROTOXIOL
-PROJECT NUMBER.01EY6234LIEBOVITCH, LARRY S ION CURRENT ANALYSS
IN THE CORNEA...1EY08299COHEN, KENNETH L PATTERN ANAYSISOFCORNEL
TOPORAPH -PROJECT NUMBER.43EY0629DO, GINA M CATARACT IMAG ANYIS
USIG NEURAL -POJECT NUMBER...EY1065IPPEON, TERESA L AUTOMATED
CORNAL ENDOTHELIAL ELMO -PROJECT NUMBER..43Y10712CHIGER, BENJAMIN
SPOKEN LANGUGE SYSTEMS FR WAYFINDI -PROJECT NUMBER.
S06GM803811MONTGOMERY, GARYT MBRS POGRAM -ROJECT NUMBER......2S0
20
6 GM08038-24   GM1432SCHERAG, HAROLD AINTERNAL BONING N PROTEINS
-PROJECT UMBER......2 R01  GM18519COREY, ELIAS J COMPUTER
ASSISTED ANALYSIS OF CHEMICA -PROJECT NUMBER..01GM2917FALK,
CATHERINE T LINKG AND ASSOCIATON OF GNETICMA -PROJECT
NUMBER..GM2958ROS, GEORGE DSEF-RECOGNITION INGLOBUAR PEINS
-PROJECT NUMBER..  GM30WATERMAN, MICHAELPATTERN RECOGITION
FORANALYSIS OF M -PROJECT NUMBERGM37408SKOLIC, JFFREY COMPUTER
SIMULATIONS AD THERY OF GL -PROJECT NUMBER.01GM3845LEARY, JAES F
HIGH-RESOLUTION MULTIPARAMETE CELL A -PROJECT
NUMBER..01GM39071HARBISON, GERARD S INTEGRATED
SOLID-STATE-SOLUTION NMR S -PROJECT NUMBER.01GM39247JAMES, THOMAS
L SOLUTIOSTRUCTURE OF DNAANDDNA-PRO -PROJECT NUMBER.. 
P13955202KUZ, IWIN D STRUCTUAL BIOLOGY AND TARGETED DRUG D -PRO 1
JECT NUMBER..P395990006 WIPKE, W TOD NEW METHODS FOR STRUCTURE
BAED DESIG -PROJCT NUMBER.. 

This is asearchable index.  Use 's' to arch E) Enter adatabase 

search string: intelligence and nutrition

Getinggopher://gopher.nih.gov/77/gopherlib/indices/crisp/index?in
telligence
Lookup gopher.ni.gov.
Making Goher connection to gopher.nih.gov.
Sending Gopher request.
Gopher requestsnt; waiting for response.
Transfered 1165 bytes  (p1 of 2
T NUMBER..   RDA04874 FRIED, PTERA PREATAL CANNABIS AND CIGATTE
CONS -PROJECT NUMBER..   
(FILE) N01HD23141 METZGER, BOYD E FOLLOW-UP OF OFFSPRING OF
DIABETIC MO -PROJECT NUMBER..
(FILE) N01HD23149 LEVY, HARVEY L MATERNAL PHENYLKETONURIA EFFECTS
ON P -PROJECTNUMBER..
(FILE) M01RR009970522 LINDEMAN, ROBERT GENERAL CLINICAL RESEARCH
CENTER -PROJECT NUMBER......5
(FILE) Z01MH00508 MIRSKY, A F NEUROPSYCHOLOGICAL EVALUATION OF
PSYC -PROJECT NUMBER..
(FILE) P01CA500870002 ABRAMS, DAVID B ACCELERATING THE PROCESS OF
CHANGE FO -PROJECT NUMBER..
(FILE) P01CA500870003 GOLDSTEIN, MICHAEL G ACCELERATING THE
PROCESS OF CHANGE FO -PROJECT NUMBER..
(FILE) P01CA500870005 PROCHASKA, JAMES O ACCELERATING THE PROCESS
OF CHANGE FO
-PROJECT NUMBER..
(FILE) P01HD319210002 ROWE, DAVID C PROSPECTIVE LONGITUDINAL
STUDY OF ADO -PROJECT NUMBER..
his is a searchale index.  Use 's' to search


   
Gettinggophe://gopher.nih.gov/0R167269825-167271451-/gopherlib/da
ta/crisp/FebHLookup gopher.ni.gov.
Making Goher connection to gopher.nih.gov.
Sending Gopher request.
Gopher requestsnt; waiting for response.
Read 82 byt of data.
61866
Datatransfer complete  M01RR009970522   LINDEMAN, ROBERTGENERAL
CLINICAL RESEARCH

-----------------------------------------------------------------
---------------
M01RR009970522   LINDEMAN, ROBERT          GENERAL CLINICAL
RESEARCH CENTER
-PROJECT NUMBER......5 M01 RR00997-19     SUB: 0522
                                     FY  94    LINDEMAN, ROBERT
IRG/INTRAMURAL UNIT..CLRUNIVERSITY OF NEW MEXICO
AWARD AMOUNT.........    $15,908               915 STANFORD NE
               ALBUQUERQUE, NM  87131
PERFORMING ORGANIZATION: UNIVERSITY OF NEW MEXICO ALBUQUERQUE
TITLE   GENERAL CLINICAL RESEARCH CENTER
  SUB TITLE NEW MEXICO SURVEY OF HEALTH IN ELDERLY HISPANICS

ABSTRACT:

This study proposes a randomly selected survey, using HCFA
Medicare
listings, a sample of 1000+ Hispanics over age 65 and a
comparable number
of non-Hispanic whites who will be approached to participate in
interviews defining heritage & other basic demographic
information & to
complete an Iowa Self Assessment Inventory.   Participants with
75% or

 
-- press pace for next page --2
more of their heritage will have examination to include dietary
intakes,
anthropometric studies, functional assessment, tests of cognitive
&
affective function, gait & balance, and blood tests.

CRISP INDEXING TERMS FROM CRISP THESAURUS:
00702889P   human old age (65+)      
23838607P   health survey
27257089P   Hispanic American
04551241S   blood test
04672059S   body composition
21164952S   diet
21166564S   nutrition of aging
40000124S   balance
40000187S   functional ability
40010057S   gait
14652234T   human subject
21166582T   nutrition related tag
24829158T   intelligence test
24835410T   neuropsychological test
.
3

Command: Use arrow keys to move, '?' for help, 'q' to quit, '<-'
to go back
Nt  searchable indexeddcument-- press '/' to search fora tex
string  
Cmmnds: Use arrow keyst move,'?' for help, 'q' to quit,'<-' o go
back
Gettig
gophr://gophr.nih.g/77/gophelib/indices/crisp/index?intelligence+
aS                                                           
(p1
T NUMBER..
(FILE) R01DA04874 FRIED, PETER A PRENATAL CANNABIS AND CIGARETTE
CONSE -PROJECTNUMBER..
(FILE) N01HD23141 METZGER, BOYD E FOLLOW-UP OF OFFSPRING OF
DIABETIC MO -PROJECT NUMBER..
(FILE) N01HD23149 LEVY, HARVEY L MATERNAL PHENYLKETONURIA EFFECTS
ON P -PROJECTNUMBER..
(FILE) M01RR009970522 LINDEMAN, ROBERT GENERAL CLINICAL RESEARCH
CENTER -PROJECT NUMBER......5
(FILE) Z01MH00508 MIRSKY, A F NEUROPSYCHOLOGICAL EVALUATION OF
PSYC -PROJECT NUMBER..
(FILE) P01CA500870002 ABRAMS, DAVID B ACCELERATING THE PROCESS OF
CHANGE FO -PROJECT NUMBER..
(FILE) P01CA500870003 GOLDSTEIN, MICHAEL G ACCELERATING THE
PROCESS OF CHANGE FO -PROJECT NUMBER..
(FILE) P01CA500870005 PROCHASKA, JAMES O ACCELERATING THE PROCESS
OF CHANGE FO
-PROJECT NUMBER..
(FILE) P01HD319210002 ROWE, DAVID C PROSPECTIVE LONGITUDINAL
STUDY OF ADO -PROJECT NUMBER..


 
This isa seachable index.  Use 's' to search
Gettinggophe://gopher.nih.gov/0R180034519-180037469-/gopherlib/da
ta/crisp/FebHLookup gopher.ni.gov.
Making Goher connection to gopher.nih.gov.
Sending Gopher request.
Gopher requestsnt; waiting for response.
Read 82 byt of data.
3017
Datatransfer complete  Z01MH00508       MIRSKY, A
FNEUROPSYCHOLOGICAL EVALUAT4

-----------------------------------------------------------------
---------------
Z01MH00508       MIRSKY, A F               NEUROPSYCHOLOGICAL
EVALUATION OF PSYC 
-PROJECT NUMBER......1 Z01 MH00508-12
         FY  94    MIRSKY, A F
IRG/INTRAMURAL UNIT..LPP                       NIMH, NIH
AWARD AMOUNT.........$0

PERFORMING ORGANIZATION:
TITLE   NEUROPSYCHOLOGICAL EVALUATION OF PSYCHIATRIC AND
NEUROLOGICAL PATIENTS 
ABSTRACT:

A set of comprehensive neuropsychological test batteries is used
to
provide a complete assessment of various cognitive and sensory
functions that can be related to damage or dysfunction in
different
regions of the brain. The adult battery comprises tests designed
to tap
the following aspects of behavior: attention, executive
functions,

 
-- press pace for next page --2
language, memory, motor functions, orientation, selected sensory
and
perceptual functions, vigilance, and visual-spatial functions. In
addition, adults are given a test of general intelligence and a
personality inventory. In some studies, subjects are administered
a
structured psychiatric interview. Modified batteries have been
developed for the assessment of infants, preschool children, and
children ages 6-16. The data provided by these batteries are
being used
to construct a neuropsychological theory of the elements of
attention
that may be applied to the neurological and psychiatric
diagnostic
groups under study in the LPP. The LPP has as its major focus
disorders
involving impaired attention, including schizophrenia, epilepsy
eating
disorders, affective disorders, head injuries. and AIDS dementia
complex. Comparisons are being carried out between the
neuropsychological profiles of various groups of psychiatric
patients
and those of patients with known cerebral lesions in specified
brain
regions. Our data are also being used to delineate
neurobehaviorally-
defined subgroups within diagnostic categories, an undertaking
aimed
at reducing variability in psychiatric diagnosis, treatment, and  

outcome. The data provided by this protocol provide a complete
behavioral assessment that may be integrated with concurrently
gathered
3
electrophysiological, neuroradiological, and biochemical
information.

CRISP INDEXING TERMS FROM CRISP THESAURUS:
04850499P   brain disorder
04893273P   brain injury
06346981P   attention deficit disorder
24835397P   neuropsychology
24836636P   mental disorder diagnosis
03855868S   behavioral medicine
04856986S   epilepsy
04960302S   brain mapping
15606280S   AIDS dementia complex
24821617S   attention
24831070S   cognition
24834698S   memory
24836430S   eating disorder
24843472S   psychomotor function
24850932S   schizophrenia
26835095S   space perception
06351343T   child (0-11)
4
06353216T   adolescence (12-20)
14652234T   human subject
15804424T   interview
21166582T   nutrition related tag
24829158T   intelligence test
24829231T   personality test
24835410Tical test
.

Command: Use arrow keys to move, '?' for help, 'q' to quit, '<-'
to go back
Gettig
gophr://gophr.nih.g/77/gophelib/indices/crisp/index?intelligence+
aS                                                       (p1 of
2
T NUMBER..  
(FILE) R01DA04874 FRIED, PETER A PRENATAL CANNABIS AND CIGARETTE
CONSE -PROJECT NUMBER..   
(FILE) N01HD23141 METZGER, BOYD E FOLLOW-UP OF OFFSPRING OF
DIABETIC MO -PROJECT NUMBER..  
(FILE) N01HD23149 LEVY, HARVEY L MATERNAL PHENYLKETONURIA EFFECTS
ON P -PROJECT NUMBER..   
(FILE) M01RR009970522 LINDEMAN, ROBERT GENERAL CLINICAL RESEARCH
CENTER -PROJECT NUMBER......5
(FILE) Z01MH00508 MIRSKY, A F NEUROPSYCHOLOGICAL EVALUATION OF
PSYC -PROJECT NUMBER..
(FILE) P01CA500870002 ABRAMS, DAVID B ACCELERATING THE PROCESS OF
CHANGE FO -PROJECT NUMBER..
(FILE) P01CA500870003 GOLDSTEIN, MICHAEL G ACCELERATING THE
PROCESS OF CHANGE FO -PROJECT NUMBER..
(FILE) P01CA500870005 PROCHASKA, JAMES O ACCELERATING THE PROCESS
OF CHANGE FO
-PROJECT NUMBER..
(FILE) P01HD319210002 ROWE, DAVID C PROSPECTIVE LONGITUDINAL
STUDY OF ADO -PROJECT NUMBER..


This isa seachable index.  Use 's' to searchEnter adatabase
search string: nutrition and aging
Getinggopher://gopher.nih.gov/77/gopherlib/indices/crisp/index?in
telligence+aSLookup gopher.ni.gov.
Making Goher connection to gopher.nih.gov.
Sending Gopher request.
Gopher requestsnt; waiting for response.
Transfered 1147 bytes229634374582572368708013915610299
bytes145225933742488360347175832294632062217672908405952266395753
686779830309872156(p1 of 21
BER.....5 P0113AG1109YU, BYUNG P PHYSIOLOGICAL BASIS OF
AGIN--MOLCUL -PROJECT NUMBER..   RAG09839ROSS, A CATHERINE
NUTRITION AND AGING--VITAMIN ANDIMMU -PROJECT
NUMBER..PAG09970ROSEMICHAEL R POSTONED AGING IN DROSOPHILA
-PRJECT NUMBR......5 P01P30DK3574011EUNG, PATICK CLINICAL
NUTRITION-PROJECT NUMBER......5 P30   P30DK357479006 HALSTED,
CHARLES  CLINICAL NUTRIRESEARH -PROJECT NUMBER.....5 P3030DK3574
HALSTED, CHARLES H CLINICAL NUTRIION ESARCH -PROJECT
NUMBER......5 P30  30DK357410TAIT, ROBERT LINICAL NUTRITION
RESEARCH -PROJECT NUMBR......5 P3030DK357493GERSWIN, M
ERICCLINICAL NUTRITIONRESEARCH -PROJECTNUMBE......5 P30  
30DK574794PHINNEY, STEPHEN D CLINICA UTRITON RESEARCH -PRJECT
NUMBER.....5 P30
(FILE) P30DK357479005 STERN, JUDITH CLINICAL NUTRITION RESEARCH
-PROJECT NUMBER
 
--More--  This isa sarchable index.  Use 's' to searchGetting
goper://gophr.nih.gov/0R9016763-9020398-/gopherlib/data/crisp/Feb
5
Lookup gopher.ni.gov.
Making Goher connection to gopher.nih.gov.
Sending Gopher request.
Gopher requestsnt; waiting for response.
Read 82 byt of data.
338 bytes of data.
594
850
116 bytes of data.
618
242
370
Datatransfer complete  R13AG11809       YU, BYUNG PPHYSIOLOGICAL
BASIS OF AGI (p1 of 4

-----------------------------------------------------------------
---------------
R13AG11809       YU, BYUNG P               PHYSIOLOGICAL BASIS OF
AGING--MOLECUL
-PROJECT NUMBER......3 R13 AG11809-01S1
          FY  94    YU, BYUNG P
IRG/INTRAMURAL UNIT..BCA                       UNIVERSITY OF
TEXAS
AWARD AMOUNT.........    $12,1607703 FLOYD CURL DRIVE
                                               SAN ANTONIO, TX 
78284-7756
PERFORMING ORGANIZATION: GERONTOLOGICAL SOCIETY OF AMERICA
TITLE   PHYSIOLOGICAL BASIS OF AGING--MOLECULE TO ORGANISM

ABSTRACT:

Financial support is requested to help fund the annual meeting of
The
Gerontological Society of America (GSA) to be held in New
Orleans, LA in
November, 1993. These funds will be used to offset the cost of
inviting
non-member symposium participants who will make substantial
contributions
to the success of the meetings. The GSA is the largest scientific
society

-- press pace for next page --2
in the United States dedicated to promoting scientific inquiry on
aging
and age-related problems. A major activity of the annual meeting
is to
facilitate better interaction, dissemination of information, and
exchange
of ideas among GSA members and non-members. The GSA meeting is
back-to-
back with the AGS and AFAR meetings.

The theme of the 1993 annual meeting of the Biological Sciences
is, "The
Physiological Basis of Aging: From Molecule to Organism". The
diversity
inherent in this theme is designed to give attendees broad,
in-depth
exposure to the major issues involved in aging research,
beginning at the 
molecular level and proceeding to the whole organism. Topics are
chosen to
address the most salient, current interests of gerontological
researchers.
Furthermore, the conference theme will encompass both theoretical
and
practical approaches to the exploration of aging processes by
critically
reappraising major hypotheses of aging and by proposing future
directions
of gerontological research. It is expected that the breadth and
depth of
this agenda will enhance not only the exchange of scholarly ideas
among 
experimental aging researchers, but will also generate excitement
for  
future research endeavors.The topics selected for the conference
plan are
organized in the following sessions: I. Evidence For/Against
Current
3
Theories of Aging. II. Interventions in the Aging Process. III.
Molecular
and Biochemical Bases of Age-Related Diseases. IV. Recent
Advances in the
Understanding of Systemic Dysfunctions in Aging. V. What is New
in
Mechanisms Underlying Dietary Restriction? VI. Cellular
Mechanisms and 
Regulation of Gene Expression in Aging. VII. Oxidative
Modification of
Cellular Constitutents in Aging. VIll. Insights into the
Molecular Biology
of the Aging Process. IX. Future Directions of Biological Aging
Research:
Panel Discussion.

The impressive advances made in the last two decades of
gerontological   
research clearly indicate that the aging phenomena involve multi-
factorial, biological processes. It follows that exploration of
these
complex biological processes requires a multi-disciplinary
approach with
resourceful, flexible experimental directions.The goal of this
meeting is
to bring together researchers with divergent interests and broad
expertise
to focus on further understanding of the mechanisms underlying
the
biological aging process.

CRISP INDEXING TERMS FROM CRISP THESAURUS:
00713613P   aging
4
15801294P   meeting /conference /symposium
13857967S   health science research
19458597S   molecular biology
21166564S   nutrition of aging
23240184S   physiology
21166582T   nutrition related tag
29690796T   travel
.


Command: Use arrow keys to move, '?' for help, 'q' to quit, '<-'
to go back
Gettig
gophr://gophr.nih.g/77/gophelib/indices/crisp/index?nutrition+and
+L                                                      (p1 of
21
BER......5 P01
(FILE) R13AG11809 YU, BYUNG P PHYSIOLOGICAL BASIS OF
AGING--MOLECUL -PROJECT NUMBER..
(FILE) R01AG09839 ROSS, A CATHERINE NUTRITION AND AGING--VITAMIN
AND IMMU -PROJECT NUMBER..
(FILE) P01AG09970 ROSE, MICHAEL R POSTONED AGING IN DROSOPHILA
-PROJECT NUMBER......5 P01  
(FILE) P30DK357470011 LEUNG, PATRICK CLINICAL NUTRITION RESEARCH
-PROJECT NUMBER......5 P30
(FILE) P30DK357479006 HALSTED, CHARLES H CLINICAL NUTRITION
RESEARCH -PROJECT NUMBER......5 P30
(FILE) P30DK35747 HALSTED, CHARLES H CLINICAL NUTRITION RESEARCH
-PROJECT NUMBER......5 P30
(FILE) P30DK357470010 TAIT, ROBERT CLINICAL NUTRITION RESEARCH
-PROJECT NUMBER......5 P30
(FILE) P30DK357479003 GERSHWIN, M ERIC CLINICAL NUTRITION
RESEARCH -PROJECT NUMBER......5 P30
(FILE) P30DK357479004 PHINNEY, STEPHEN D CLINICAL NUTRITION
RESEARCH -PROJECT NUMBER......5 P30
(FILE) P30DK357479005 STERN, JUDITH CLINICAL NUTRITION RESEARCH
-PROJECT NUMBER
 
--More--  Tis is a sarchable index.  Use 's' to search E) Getting
goper://gophr.nih.gov/0R6708156-6711900-/gopherlib/data/crisp/Feb
5
Lookup gopher.ni.gov.
Making Goher connection to gopher.nih.gov.
Sending Gopher request.
Gopher requestsnt; waiting for response.
Read 82 byt of data.
3815
Datatransfer complete  R01AG09839       ROSS, A
CATHERINENUTRITION AND AGING--VITAM (p1 of 4

-----------------------------------------------------------------
---------------
R01AG09839       ROSS, A CATHERINE         NUTRITION AND
AGING--VITAMIN AND IMMU
-PROJECT NUMBER......7 R01 AG09839-04
          FY  94    ROSS, A CATHERINE
IRG/INTRAMURAL UNIT..NTN                       PENNSYLVANIA STATE
UNIVERSITY   AWARD AMOUNT.........   $164,419
                                               UNIVERSITY PARK,
PA  16802
PERFORMING ORGANIZATION: PENNSYLVANIA STATE UNIVERSITY-UNIV PARK
TITLE   NUTRITION AND AGING--VITAMIN AND IMMUNE FUNCTION

ABSTRACT:

DESCRIPTION (Investigator's Abstract):  It is well established
that immune
responses tend to decrease as humans and animals enter old age. 
The role
of the chronic diet may play in modulating age-related changes in
immune
functions is not well understood.  Vitamin A (retinol) status may
be
particularly pertinent because of the demonstrated effects of
retinoids on

-- press pace for next page --2
cellular growth, differentiation and function.  The investigator
proposes
to use the Fischer 344 rat as a model of aging to explore the
effects of
chronic diet on two major aspects of immune function:  antibody
production
elicited by pneumococcal polysaccharide, a clinically important
antigen in
the aged population, and natural killer (NK) cell function, an
aspect of
antibody-independent immunity implicated in tumor surveillance
and in
regulation of the antibody responses.  The first two specific
aims will
establish (1) appropriate doses of antigen and timing of antibody 
production to pneumococcal polysaccharide in rats of various
ages, and (2)
appropriate dietary conditions to maintain rats in a chronic
marginal
vitamin A status or a retinol-abundant status.  Specific aim 3 is
designed
to address the following questions:  Does a chronic diet that is
marginal
in vitamin A exacerbate the age-related decrease in immune
functions?  Will
chronic dietary supplementation with vitamin A significantly
increase (or
possibly suppress) immune responses?  Animals will be studied at
four ages
so as to compare the responses of young, adult, "aging" and
elderly 
animals.  In Aim 4, the investigator will determine whether the  
retinol-enriched diet has deleterious effects, e.g., on serum
lipid
concentrations or liver function.  The goal of Aim 5 is to
determin
whether administration of retinol acutely can overcome the 
3
immunosuppressive effects of age in animals fed a diet
chronically marginal
in retinol.  Aim 6 will explore the hypothesis that vitamin A
affects   
immune functions, at least in part, through its action on
macrophages
and/or NK cells via the soluble factors they elaborate.  The
investigators
will conduct a series of mechanistic studies focused on the
response to 
lipopolysaccharide and lymphokines or cytokines, particularly
interleukin-1B, tumor necrosis factor-alpha, and immune
interferon which
may regulate the antibody response to pneumococcal polysaccharide
and/or
cytotoxicity by NK cells.  In all, the proposed investigations
will help to
understand the role of chronic diet in the immune response to
infectious
disease and in natural immunity throughout the life span.

CRISP INDEXING TERMS FROM CRISP THESAURUS:
15532789P   immunity
15562459P   antibody formation
21166564P   nutrition of aging 
31473843P   all trans retinol
04326461S   macrophage
04354050S   natural killer cell
15535631S   bactericidal immunity 

Getting
goher://gopher.nih.gov/77/gopherlib/indices/crisp/index?nutrition
+and+L                                                           
(p1 of 21
BER......5 P01
(FILE) R13AG11809 YU, BYUNG P PHYSIOLOGICAL BASIS OF
AGING--MOLECUL -PROJECT NUMBER.. 
(FILE) R01AG09839 ROSS, A CATHERINE NUTRITION AND AGING--VITAMIN
AND IMMU -PROJECT NUMBER.. 
(FILE) P01AG09970 ROSE, MICHAEL R POSTONED AGING IN DROSOPHILA
-PROJECT NUMBER......5 P01
(FILE) P30DK357470011 LEUNG, PATRICK CLINICAL NUTRITION RESEARCH
-PROJECT NUMBER......5 P30 
(FILE) P30DK357479006 HALSTED, CHARLES H CLINICAL NUTRITION
RESEARCH -PROJECT NUMBER......5 P30
(FILE) P30DK35747 HALSTED, CHARLES H CLINICAL NUTRITION RESEARCH
-PROJECT NUMBER......5 P30
(FILE) P30DK357470010 TAIT, ROBERT CLINICAL NUTRITION RESEARCH
-PROJECT NUMBER......5 P30  
(FILE) P30DK357479003 GERSHWIN, M ERIC CLINICAL NUTRITION
RESEARCH -PROJECT NUMBER......5 P30
(FILE) P30DK357479004 PHINNEY, STEPHEN D CLINICAL NUTRITION
RESEARCH -PROJECT NUMBER......5 P30
(FILE) P30DK357479005 STERN, JUDITH CLINICAL NUTRITION RESEARCH
-PROJECT NUMBER
 
--More--  Tis is a sarchable index.  Use 's' to search E)   
Getting
goper://gophr.nih.gov/0R73309909-73312788-/gopherlib/data/crisp/F
eb5
Lookup gopher.ni.gov.
Making Goher connection to gopher.nih.gov.
Sending Gopher request.
Gopher requestsnt; waiting for response.
Read 82 byt of data.
2949
Datatransfer complete  P30DK357479006   HALSTED, CHARLES
HCLINICAL NUTRITION RESEARC (p1 of 4

-----------------------------------------------------------------
---------------
P30DK357479006   HALSTED, CHARLES H        CLINICAL NUTRITION
RESEARCH
-PROJECT NUMBER......5 P30 DK35747-09     SUB: 9006
                                     FY  94    HALSTED, CHARLES H
IRG/INTRAMURAL UNIT..DDKUNIVERSITY OF CALIFORNIA
AWARD AMOUNT.........   $130,833               TB 156, SCHOOL OF
MEDICINE
            DAVIS, CA  95616
PERFORMING ORGANIZATION: UNIVERSITY OF CALIFORNIA DAVIS
TITLE   CLINICAL NUTRITION RESEARCH
  SUB TITLE CORE--CLINICAL NUTRITION SUPPORT LABORATORY

ABSTRACT:


  SUBPROJECT ABSTRACT NOT AVAILABLE.  PARENT ABSTRACT:

The overall objective of the Clinical Nutrition Research Unit
(CNRU) is to
provide an environment that fosters interdisciplinary
collaborations

-- press pace for next page --2
between basic and clinical nutrition scientists to promote
excellence in
research and thereby to strengthen the role of clinical nutrition
in
academic medicine.  The CNRU encompasses three major research
themes:

1. nutrition and diseases (AIDS, alcoholism, aging disorders,
diabetes,
heart disease, inflammatory disease, intestinal diseases and
metabolism,
and nutrition support of medical and surgical illness),

2. energy intake and metabolism (obesity, eating disorders), and

3. nutrition and development (perinatal development, infant
nutrition, and
extracellular matrix disorders).

The CNRU has six specific aims:

1. to provide Core Laboratories to facilitate collaborative
research,
including a) Clinical Nutrition Support (with Intestinal
Absorption &
Nutrient Balance, Vitamin & Mineral, and Lipoprotein Subcores),
b)
Metabolism (with Stable Isotope Subcore), c) Animal Models, d)
Molecular &
Cell Biology, and e) Administration;
3

2. to implement a Pilot & Feasibility Program and New
Investigator Award to
encourage young investigators and new approaches in clinical
nutrition;

3. to carry out an enrichment program, including weekly in-depth
scientific
seminars and annual visiting professors;

4. to provide research training for postdoctoral PhDs and
postgraduate MDs,
thereby increasing the viability of clinical nutrition as a
career choice
and expanding the number of academic nutritionists;

5. to strengthen existing nutrition support services by providing
essential
laboratory services, thereby increasing opportunities for
clinical
investigations of hospitalized patients; and

6. to disseminate nutrient information to health professionals
and the
public.

CRISP INDEXING TERMS FROM CRISP THESAURUS:
04190946P   biomedical facility
4
06335423P   clinical chemistry
21164900P   nutrition
12488056S   gastrointestinal nutrient absorption 
18500312S   metabolism
20773443S   nitrogen balance
06335765T   feces analysis
21166582T   nutrition related tag
28713456T   lyophilization
28713944T   calorimetry
.

Command: Use arrow keys to move, '?' for help, 'q' to quit, '<-'
to go back
Gettig
gophr://gophr.nih.g/77/gophelib/indices/crisp/index?nutrition+and
+L                                                            
(p1 of 21
BER......5 P01
(FILE) R13AG11809 YU, BYUNG P PHYSIOLOGICAL BASIS OF
AGING--MOLECUL -PROJECT NUMBER..
(FILE) R01AG09839 ROSS, A CATHERINE NUTRITION AND AGING--VITAMIN
AND IMMU -PROJECT NUMBER..
(FILE) P01AG09970 ROSE, MICHAEL R POSTONED AGING IN DROSOPHILA
-PROJECT NUMBER......5 P01  
(FILE) P30DK357470011 LEUNG, PATRICK CLINICAL NUTRITION RESEARCH
-PROJECT NUMBER......5 P30
(FILE) P30DK357479006 HALSTED, CHARLES H CLINICAL NUTRITION
RESEARCH -PROJECT NUMBER......5 P30
(FILE) P30DK35747 HALSTED, CHARLES H CLINICAL NUTRITION RESEARCH
-PROJECT NUMBER......5 P30
(FILE) P30DK357470010 TAIT, ROBERT CLINICAL NUTRITION RESEARCH
-PROJECT NUMBER......5 P30
(FILE) P30DK357479003 GERSHWIN, M ERIC CLINICAL NUTRITION
RESEARCH -PROJECT NUMBER......5 P30
(FILE) P30DK357479004 PHINNEY, STEPHEN D CLINICAL NUTRITION
RESEARCH -PROJECT NUMBER......5 P30
(FILE) P30DK357479005 STERN, JUDITH CLINICAL NUTRITION RESEARCH
-PROJECT NUMBER
 
--More--  Tis is a sarchable index.  Use 's' to search Getting
goper://gophr.nih.gov/77/gopherlib/indices/crisp/index?intelligen
ce+aS (p1 of 2
T NUMBER. 01DA0474FRIED, PETER A PRENATAL CANNABIS AND CIARETT
CONSE -PROJECT NUMBER..NHD23141METZGER, BOYD E FOLLOW-UP OF
OFFSPRING OF DIABETICMO -PROJECT NUMBER..  NHD23149LEVYHARVEY L
MATERNAL PHENYLKETONURIA EFFECTS N P -PROJCT NUMBER..
M01RR0099522INDEMAN, OBERT GENERAL CLINICALCENTER -PROJECT
NUMBER......5Z01MH00508 MIRSKY, A F NEUROPSYCOLOGICAL EVALUAOF
PSY -PROJECT NUMBER.01CA50080002 ABRAMS, DAVID B ACCELERATING HE
POCSS OF CHANGE FO -PROJECT NUMBER..01CA500803GOLDSTEIN, MIHAEL G
ACCELERATING THE PROCESS OF CHANG FO -PROJECT
NUMBER..01CA500805PROCASKA, JAMESO ACCELERATING THEPROCESS OF
CHANGEFO -POJECT NUMBER..01HD192102ROWE, DAVID C PROSPECTIVE
OGITUDNAL STUDY OF AD -PROJECT NUMBER. 


 
This isa seachable index.  Use 's' to
searchGettinggophe://gopher.nih.gov/77/gopherlib/indices/crisp/in
dex?intelligence(p21 of 21
JECT NUMBER..PGM395990006 WIPK, WTODD EW METHODS FOR STRUCTU
BASED DSIG -PROJECT NUMBER..

This isa seachable index.  Use 's' to search E)
Gettinggophe://gopher.nih.gov/77/gopherlib/indices/crisp/index?rd
i

   Select one of:

(FILE) P50HL422150006 VAN LUNTEREN, ERIK SCOR IN CARDIOPULMONARY
DISORDERS OF -PROJECT NUMBER...
This isa seachable index.  Use 's' to search
Gettinggophe://gopher.nih.gov/77/gopherlib/indices/crisp/index?rd
i+and+seleniILookup gopher.ni.gov.
Making Goher connection to gopher.nih.gov.
Sending Gopher request.
Gopher requestsnt; waiting for response.


 
This is a sarchableindex. Use's' to search
Gettinggophe://gopher.nih.gov/77/gopherlib/indices/crisp/index?

athersclerosisGLookup gopher.ni.gov.

Making Goher connection to gopher.nih.gov.
Sending Gopher request.
Gopher requestsnt; waiting for response.(FILE) R01HL42392
WEINBERGER, JUDAH Z CELLULAR METABOLISM IN RESPONSE TO HY
-PROJECT NUMBER..

 
This is a sarchableindex. Use's' to search 
Gettinghttp://atsdr1.atsdr.cdc.gov:8080/cx.html
Lookup atsdr1.atsdr.ccgov:8080.
Making HTTP connection to atsdr1.atsdr.cdc.gov:8080.
Sending HTP request.
HTTP requestsnt; waiting for response.
Read256 bye of data.of 32486byes of data.
12800 of 32486 bytes of data.
32413
DatatransfercompleteATSDR Science Corner (p33 of 45)* CRISP (NIH
Searchable Gopher Index):
   This is the searchable version of the biomedical information
       database on research supported by the Public Health
Service (PHS)
       and intramural research programs of the National
Institutes ofHealth (NIH) and the Food and Drug Administration
(FDA).The NIH CRISP (Computer Retrieval of Information on
ScientificProjects) provides an abstract for each research grant
funded anddetails to contact the principal investigator. Contains
a goodlisting of biomedical research grants in support of
Superfundresearch.

     * Yahoo - A Guide to the WWW:This resource provides an
almost "endless" list of resources thatare organized in a simple
and useful hierarchy. There is a"search" function available.
Also, there is a direct connection to"WebCrawler" and other
search engines for additional searchcapability.

-- press pace for next page --Getting
http://atsdr1.atsdr.cdc.gov:8080/tfacts13.html
